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A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers
The therapeutic efficacy of nanoscale drug delivery systems is related to particle size, zeta potential, morphology, and other physicochemical properties. The structure and composition of nanocarriers may affect their physicochemical properties. To systematically evaluate these characteristics, thre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921568/ https://www.ncbi.nlm.nih.gov/pubmed/36770710 http://dx.doi.org/10.3390/molecules28031040 |
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author | Zhang, Yansong Ding, Lijuan Wang, Ting Wang, Xiangtao Yu, Bo Jia, Fei Han, Meihua Guo, Yifei |
author_facet | Zhang, Yansong Ding, Lijuan Wang, Ting Wang, Xiangtao Yu, Bo Jia, Fei Han, Meihua Guo, Yifei |
author_sort | Zhang, Yansong |
collection | PubMed |
description | The therapeutic efficacy of nanoscale drug delivery systems is related to particle size, zeta potential, morphology, and other physicochemical properties. The structure and composition of nanocarriers may affect their physicochemical properties. To systematically evaluate these characteristics, three analogues, namely polyethylene glycol (PEG), PEG-conjugated octadecylamine (PEG-C18), and tri(ethylene glycol) (TEG), were explored as nanocarriers to entrap celastrol (CSL) via the injection-combined dialysis method. CSL nanoparticles were successfully prepared as orange milky solutions, which revealed a similar particle size of approximately 120 nm, with narrow distribution and a negative zeta potential of −20 mV. All these CSL nanoparticles exhibited good storage stability and media stability but presented different drug-loading capacities (DLCs), release profiles, cytotoxicity, and hemolytic activity. For DLCs, PEG-C18/CSL exhibited better CSL entrapment capacity. Regarding the release profiles, TEG/CSL showed the lowest release rate, PEG-C18/CSL presented a moderate release rate, and PEG/CSL exhibited a relatively fast release rate. Based on the different release rates, PEG-C18/CSL and TEG/CSL showed higher degrees of cytotoxicity than PEG/CSL. Furthermore, TEG/CSL showed the lowest membrane toxicity, and its hemolytic rate was below 20%. These results suggest that the structural effects of nanocarriers can affect the interactions between nanocarriers and drugs, resulting in different release profiles and antitumor activity. |
format | Online Article Text |
id | pubmed-9921568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99215682023-02-12 A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers Zhang, Yansong Ding, Lijuan Wang, Ting Wang, Xiangtao Yu, Bo Jia, Fei Han, Meihua Guo, Yifei Molecules Article The therapeutic efficacy of nanoscale drug delivery systems is related to particle size, zeta potential, morphology, and other physicochemical properties. The structure and composition of nanocarriers may affect their physicochemical properties. To systematically evaluate these characteristics, three analogues, namely polyethylene glycol (PEG), PEG-conjugated octadecylamine (PEG-C18), and tri(ethylene glycol) (TEG), were explored as nanocarriers to entrap celastrol (CSL) via the injection-combined dialysis method. CSL nanoparticles were successfully prepared as orange milky solutions, which revealed a similar particle size of approximately 120 nm, with narrow distribution and a negative zeta potential of −20 mV. All these CSL nanoparticles exhibited good storage stability and media stability but presented different drug-loading capacities (DLCs), release profiles, cytotoxicity, and hemolytic activity. For DLCs, PEG-C18/CSL exhibited better CSL entrapment capacity. Regarding the release profiles, TEG/CSL showed the lowest release rate, PEG-C18/CSL presented a moderate release rate, and PEG/CSL exhibited a relatively fast release rate. Based on the different release rates, PEG-C18/CSL and TEG/CSL showed higher degrees of cytotoxicity than PEG/CSL. Furthermore, TEG/CSL showed the lowest membrane toxicity, and its hemolytic rate was below 20%. These results suggest that the structural effects of nanocarriers can affect the interactions between nanocarriers and drugs, resulting in different release profiles and antitumor activity. MDPI 2023-01-20 /pmc/articles/PMC9921568/ /pubmed/36770710 http://dx.doi.org/10.3390/molecules28031040 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Yansong Ding, Lijuan Wang, Ting Wang, Xiangtao Yu, Bo Jia, Fei Han, Meihua Guo, Yifei A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title | A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title_full | A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title_fullStr | A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title_full_unstemmed | A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title_short | A Celastrol Drug Delivery System Based on PEG Derivatives: The Structural Effects of Nanocarriers |
title_sort | celastrol drug delivery system based on peg derivatives: the structural effects of nanocarriers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921568/ https://www.ncbi.nlm.nih.gov/pubmed/36770710 http://dx.doi.org/10.3390/molecules28031040 |
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