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Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives

Ginsenosides are major bioactive compounds present in the Panax species. Ginsenosides exhibit various pharmaceutical properties, including anticancer, anti-inflammatory, antimetastatic, hypertension, and neurodegenerative disorder activities. Although several commercial products have been presented...

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Detalles Bibliográficos
Autores principales: Chu, Luan Luong, Huy, Nguyen Quang, Tung, Nguyen Huu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921939/
https://www.ncbi.nlm.nih.gov/pubmed/36771109
http://dx.doi.org/10.3390/molecules28031437
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author Chu, Luan Luong
Huy, Nguyen Quang
Tung, Nguyen Huu
author_facet Chu, Luan Luong
Huy, Nguyen Quang
Tung, Nguyen Huu
author_sort Chu, Luan Luong
collection PubMed
description Ginsenosides are major bioactive compounds present in the Panax species. Ginsenosides exhibit various pharmaceutical properties, including anticancer, anti-inflammatory, antimetastatic, hypertension, and neurodegenerative disorder activities. Although several commercial products have been presented on the market, most of the current chemical processes have an unfriendly environment and a high cost of downstream processing. Compared to plant extraction, microbial production exhibits high efficiency, high selectivity, and saves time for the manufacturing of industrial products. To reach the full potential of the pharmaceutical resource of ginsenoside, a suitable microorganism has been developed as a novel approach. In this review, cell biological mechanisms in anticancer activities and the present state of research on the production of ginsenosides are summarized. Microbial hosts, including native endophytes and engineered microbes, have been used as novel and promising approaches. Furthermore, the present challenges and perspectives of using microbial hosts to produce ginsenosides have been discussed.
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spelling pubmed-99219392023-02-12 Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives Chu, Luan Luong Huy, Nguyen Quang Tung, Nguyen Huu Molecules Review Ginsenosides are major bioactive compounds present in the Panax species. Ginsenosides exhibit various pharmaceutical properties, including anticancer, anti-inflammatory, antimetastatic, hypertension, and neurodegenerative disorder activities. Although several commercial products have been presented on the market, most of the current chemical processes have an unfriendly environment and a high cost of downstream processing. Compared to plant extraction, microbial production exhibits high efficiency, high selectivity, and saves time for the manufacturing of industrial products. To reach the full potential of the pharmaceutical resource of ginsenoside, a suitable microorganism has been developed as a novel approach. In this review, cell biological mechanisms in anticancer activities and the present state of research on the production of ginsenosides are summarized. Microbial hosts, including native endophytes and engineered microbes, have been used as novel and promising approaches. Furthermore, the present challenges and perspectives of using microbial hosts to produce ginsenosides have been discussed. MDPI 2023-02-02 /pmc/articles/PMC9921939/ /pubmed/36771109 http://dx.doi.org/10.3390/molecules28031437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chu, Luan Luong
Huy, Nguyen Quang
Tung, Nguyen Huu
Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title_full Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title_fullStr Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title_full_unstemmed Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title_short Microorganisms for Ginsenosides Biosynthesis: Recent Progress, Challenges, and Perspectives
title_sort microorganisms for ginsenosides biosynthesis: recent progress, challenges, and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921939/
https://www.ncbi.nlm.nih.gov/pubmed/36771109
http://dx.doi.org/10.3390/molecules28031437
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