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Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms

The morbidity and mortality of BCR-ABL-negative myeloproliferative neoplasia (MPN) patients is highly dependent on thrombosis that may be affected by antiphospholipid antibodies (aPLA) and lupus anticoagulant. Our aim was to evaluate the association of the aPLA together with platelet receptor glycop...

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Autores principales: Dambrauskienė, Rūta, Gerbutavičius, Rolandas, Rudžianskienė, Milda, Paukštaitienė, Renata, Vitkauskienė, Astra, Skrodenienė, Erika, Remeikienė, Diana, Zaborienė, Inga, Juozaitytė, Elona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922056/
https://www.ncbi.nlm.nih.gov/pubmed/36816798
http://dx.doi.org/10.1515/biol-2022-0545
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author Dambrauskienė, Rūta
Gerbutavičius, Rolandas
Rudžianskienė, Milda
Paukštaitienė, Renata
Vitkauskienė, Astra
Skrodenienė, Erika
Remeikienė, Diana
Zaborienė, Inga
Juozaitytė, Elona
author_facet Dambrauskienė, Rūta
Gerbutavičius, Rolandas
Rudžianskienė, Milda
Paukštaitienė, Renata
Vitkauskienė, Astra
Skrodenienė, Erika
Remeikienė, Diana
Zaborienė, Inga
Juozaitytė, Elona
author_sort Dambrauskienė, Rūta
collection PubMed
description The morbidity and mortality of BCR-ABL-negative myeloproliferative neoplasia (MPN) patients is highly dependent on thrombosis that may be affected by antiphospholipid antibodies (aPLA) and lupus anticoagulant. Our aim was to evaluate the association of the aPLA together with platelet receptor glycoprotein (GP) Ia/IIa c.807C>T CT/TT genotypes and thrombotic complications in patients with MPNs. The study included 108 patients with BCR-ABL-negative MPN with data of previous thrombosis. Two different screening and one confirmatory test for the lupus anticoagulant were performed. Thrombotic complications were present in 59 (54.6%) subjects. aPLA were more frequently found in MPN patients with thrombosis vs no thrombosis (25.4 and 6.1%; p = 0.007). MPN patients with arterial thrombosis were more frequently positive for aPLA vs no arterial thrombosis (38.8 and 11.9%; p = 0.001). aPLA were more frequently found in patients with cerebrovascular events vs other arterial thrombotic complications or no thrombosis, respectively (39.3, 6.1, and 12.9%; p < 0.001). MPN patients with thrombosis were more frequently positive with aPLA and had platelet receptor GP Ia/IIa c.807C>T CT/TT genotypes compared to MPN patients without thrombosis (18.6 and 2.0%; p = 0.006). aPLA alone or with coexistence with platelet receptor GP Ia/IIa c.807C>T CT/TT polymorphism could be associated with thrombotic complications in patients with MPN.
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spelling pubmed-99220562023-02-16 Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms Dambrauskienė, Rūta Gerbutavičius, Rolandas Rudžianskienė, Milda Paukštaitienė, Renata Vitkauskienė, Astra Skrodenienė, Erika Remeikienė, Diana Zaborienė, Inga Juozaitytė, Elona Open Life Sci Research Article The morbidity and mortality of BCR-ABL-negative myeloproliferative neoplasia (MPN) patients is highly dependent on thrombosis that may be affected by antiphospholipid antibodies (aPLA) and lupus anticoagulant. Our aim was to evaluate the association of the aPLA together with platelet receptor glycoprotein (GP) Ia/IIa c.807C>T CT/TT genotypes and thrombotic complications in patients with MPNs. The study included 108 patients with BCR-ABL-negative MPN with data of previous thrombosis. Two different screening and one confirmatory test for the lupus anticoagulant were performed. Thrombotic complications were present in 59 (54.6%) subjects. aPLA were more frequently found in MPN patients with thrombosis vs no thrombosis (25.4 and 6.1%; p = 0.007). MPN patients with arterial thrombosis were more frequently positive for aPLA vs no arterial thrombosis (38.8 and 11.9%; p = 0.001). aPLA were more frequently found in patients with cerebrovascular events vs other arterial thrombotic complications or no thrombosis, respectively (39.3, 6.1, and 12.9%; p < 0.001). MPN patients with thrombosis were more frequently positive with aPLA and had platelet receptor GP Ia/IIa c.807C>T CT/TT genotypes compared to MPN patients without thrombosis (18.6 and 2.0%; p = 0.006). aPLA alone or with coexistence with platelet receptor GP Ia/IIa c.807C>T CT/TT polymorphism could be associated with thrombotic complications in patients with MPN. De Gruyter 2023-02-07 /pmc/articles/PMC9922056/ /pubmed/36816798 http://dx.doi.org/10.1515/biol-2022-0545 Text en © 2023 the author(s), published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Dambrauskienė, Rūta
Gerbutavičius, Rolandas
Rudžianskienė, Milda
Paukštaitienė, Renata
Vitkauskienė, Astra
Skrodenienė, Erika
Remeikienė, Diana
Zaborienė, Inga
Juozaitytė, Elona
Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title_full Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title_fullStr Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title_full_unstemmed Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title_short Antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
title_sort antiphospholipid antibodies and the risk of thrombosis in myeloproliferative neoplasms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922056/
https://www.ncbi.nlm.nih.gov/pubmed/36816798
http://dx.doi.org/10.1515/biol-2022-0545
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