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Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway

RESULTS: EA intervention and OxPAPC injection could relieve mechanical allodynia and thermal hyperalgesia caused by CIA. Paw edema and pathological damage of synovium were significantly ameliorated after EA intervention and OxPAPC injection. Furthermore, EA intervention and OxPAPC injection markedly...

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Autores principales: Sun, Shi-Yue, Yan, Qi-Qi, Qiao, Li-Na, Shi, Yi-Nan, Tan, Lian-Hong, Yang, Yong-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922193/
https://www.ncbi.nlm.nih.gov/pubmed/36785752
http://dx.doi.org/10.1155/2023/9050763
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author Sun, Shi-Yue
Yan, Qi-Qi
Qiao, Li-Na
Shi, Yi-Nan
Tan, Lian-Hong
Yang, Yong-Sheng
author_facet Sun, Shi-Yue
Yan, Qi-Qi
Qiao, Li-Na
Shi, Yi-Nan
Tan, Lian-Hong
Yang, Yong-Sheng
author_sort Sun, Shi-Yue
collection PubMed
description RESULTS: EA intervention and OxPAPC injection could relieve mechanical allodynia and thermal hyperalgesia caused by CIA. Paw edema and pathological damage of synovium were significantly ameliorated after EA intervention and OxPAPC injection. Furthermore, EA intervention and OxPAPC injection markedly reduced the contents of serum TNF-α, IL-1β, and IL-6, as well as the protein expression levels of synovial TLR2, TLR4, MyD88, and NF-κB p-p65. In particular, the expression of TLR2 and TLR4 on synovial fibroblasts and macrophages in synovium was significantly reduced by EA intervention. CONCLUSIONS: Repeated EA stimulation at ST36 and SP6 can effectively relieve joint pain and synovial inflammation caused by RA in CIA rats. The analgesic and anti-inflammatory effect of EA may be closely related to the inhibition of innate immune responses driven by the TLR2/4-MyD88-NF-κB signaling pathway in the synovium.
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spelling pubmed-99221932023-02-12 Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway Sun, Shi-Yue Yan, Qi-Qi Qiao, Li-Na Shi, Yi-Nan Tan, Lian-Hong Yang, Yong-Sheng Evid Based Complement Alternat Med Research Article RESULTS: EA intervention and OxPAPC injection could relieve mechanical allodynia and thermal hyperalgesia caused by CIA. Paw edema and pathological damage of synovium were significantly ameliorated after EA intervention and OxPAPC injection. Furthermore, EA intervention and OxPAPC injection markedly reduced the contents of serum TNF-α, IL-1β, and IL-6, as well as the protein expression levels of synovial TLR2, TLR4, MyD88, and NF-κB p-p65. In particular, the expression of TLR2 and TLR4 on synovial fibroblasts and macrophages in synovium was significantly reduced by EA intervention. CONCLUSIONS: Repeated EA stimulation at ST36 and SP6 can effectively relieve joint pain and synovial inflammation caused by RA in CIA rats. The analgesic and anti-inflammatory effect of EA may be closely related to the inhibition of innate immune responses driven by the TLR2/4-MyD88-NF-κB signaling pathway in the synovium. Hindawi 2023-02-04 /pmc/articles/PMC9922193/ /pubmed/36785752 http://dx.doi.org/10.1155/2023/9050763 Text en Copyright © 2023 Shi-Yue Sun et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Shi-Yue
Yan, Qi-Qi
Qiao, Li-Na
Shi, Yi-Nan
Tan, Lian-Hong
Yang, Yong-Sheng
Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title_full Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title_fullStr Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title_full_unstemmed Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title_short Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway
title_sort electroacupuncture alleviates pain responses and inflammation in collagen-induced arthritis rats via suppressing the tlr2/4-myd88-nf-κb signaling pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922193/
https://www.ncbi.nlm.nih.gov/pubmed/36785752
http://dx.doi.org/10.1155/2023/9050763
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