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Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma

Respiratory oscillometry is widely explored in asthma management; however, there is currently no consensus on its routine work-up in patients with difficult-to-treat asthma. We conducted a retrospective, cross-sectional study involving patients with difficult-to-treat asthma at Asia University Hospi...

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Autores principales: Shen, Yi-Luen, Hsieh, Yi-An, Huang, Yu-Ming, Peng, Yi-Hao, Chen, Ling-I, Dai, Fang-Chuan, Lin, Yu-Sheng, Huang, Chien-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922248/
https://www.ncbi.nlm.nih.gov/pubmed/36774404
http://dx.doi.org/10.1038/s41598-023-29672-z
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author Shen, Yi-Luen
Hsieh, Yi-An
Huang, Yu-Ming
Peng, Yi-Hao
Chen, Ling-I
Dai, Fang-Chuan
Lin, Yu-Sheng
Huang, Chien-Wen
author_facet Shen, Yi-Luen
Hsieh, Yi-An
Huang, Yu-Ming
Peng, Yi-Hao
Chen, Ling-I
Dai, Fang-Chuan
Lin, Yu-Sheng
Huang, Chien-Wen
author_sort Shen, Yi-Luen
collection PubMed
description Respiratory oscillometry is widely explored in asthma management; however, there is currently no consensus on its routine work-up in patients with difficult-to-treat asthma. We conducted a retrospective, cross-sectional study involving patients with difficult-to-treat asthma at Asia University Hospital between January 2017 and October 2020. We aimed to correlate clinical significance of respiratory oscillometry and asthma treatment outcomes including symptoms control and exacerbation in patients with difficult-to-treat asthma. Among the 69 patients enrolled in the study, a total of 26.1% of the patients experienced at least one severe or two moderate exacerbations. Patients with ACT < 20 presented a higher prevalence of higher frequency-dependent resistance (FDR; the difference in resistance at 5 Hz and 20 Hz) and frequency of resonance (Fres) than those with ACT ≥ 20. In the multivariable analysis, comorbidities, COPD or allergic rhinitis, and FDR were independent factors in increasing the odds ratio in poorly controlled asthma. (FDR ≥ 0.10 vs. < 0.10, adjusted ORR = 5.05, P = 0.037) There was a higher proportion of frequent exacerbations in patients with higher FDR (FDR ≥ 0.10 vs. < 0.10 = 30.0%:20.7%), but IOS parameters failed to predict frequent exacerbations on further analysis. FDR may be a potential clinical parameter for predicting symptom control in patients with difficult-to-treat asthma.
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spelling pubmed-99222482023-02-13 Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma Shen, Yi-Luen Hsieh, Yi-An Huang, Yu-Ming Peng, Yi-Hao Chen, Ling-I Dai, Fang-Chuan Lin, Yu-Sheng Huang, Chien-Wen Sci Rep Article Respiratory oscillometry is widely explored in asthma management; however, there is currently no consensus on its routine work-up in patients with difficult-to-treat asthma. We conducted a retrospective, cross-sectional study involving patients with difficult-to-treat asthma at Asia University Hospital between January 2017 and October 2020. We aimed to correlate clinical significance of respiratory oscillometry and asthma treatment outcomes including symptoms control and exacerbation in patients with difficult-to-treat asthma. Among the 69 patients enrolled in the study, a total of 26.1% of the patients experienced at least one severe or two moderate exacerbations. Patients with ACT < 20 presented a higher prevalence of higher frequency-dependent resistance (FDR; the difference in resistance at 5 Hz and 20 Hz) and frequency of resonance (Fres) than those with ACT ≥ 20. In the multivariable analysis, comorbidities, COPD or allergic rhinitis, and FDR were independent factors in increasing the odds ratio in poorly controlled asthma. (FDR ≥ 0.10 vs. < 0.10, adjusted ORR = 5.05, P = 0.037) There was a higher proportion of frequent exacerbations in patients with higher FDR (FDR ≥ 0.10 vs. < 0.10 = 30.0%:20.7%), but IOS parameters failed to predict frequent exacerbations on further analysis. FDR may be a potential clinical parameter for predicting symptom control in patients with difficult-to-treat asthma. Nature Publishing Group UK 2023-02-11 /pmc/articles/PMC9922248/ /pubmed/36774404 http://dx.doi.org/10.1038/s41598-023-29672-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shen, Yi-Luen
Hsieh, Yi-An
Huang, Yu-Ming
Peng, Yi-Hao
Chen, Ling-I
Dai, Fang-Chuan
Lin, Yu-Sheng
Huang, Chien-Wen
Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title_full Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title_fullStr Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title_full_unstemmed Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title_short Assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
title_sort assessing the prognostic value of respiratory oscillometry in patients with difficult-to-treat asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922248/
https://www.ncbi.nlm.nih.gov/pubmed/36774404
http://dx.doi.org/10.1038/s41598-023-29672-z
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