CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma

In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, we show that CDK5RAP2 is highly expressed in OSCC and its expression correlates with clinic...

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Autores principales: Shen, Yuehong, Chen, Yuling, Lin, Yuntao, Li, Yicun, Liu, Pengfei, Zhang, Biru, Wang, Yufan, Chan, King-Chi, Mak, Nai-Ki, Kahn, Michael, Qi, Robert Z., Yang, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922250/
https://www.ncbi.nlm.nih.gov/pubmed/36774351
http://dx.doi.org/10.1038/s41419-023-05652-z
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author Shen, Yuehong
Chen, Yuling
Lin, Yuntao
Li, Yicun
Liu, Pengfei
Zhang, Biru
Wang, Yufan
Chan, King-Chi
Mak, Nai-Ki
Kahn, Michael
Qi, Robert Z.
Yang, Hongyu
author_facet Shen, Yuehong
Chen, Yuling
Lin, Yuntao
Li, Yicun
Liu, Pengfei
Zhang, Biru
Wang, Yufan
Chan, King-Chi
Mak, Nai-Ki
Kahn, Michael
Qi, Robert Z.
Yang, Hongyu
author_sort Shen, Yuehong
collection PubMed
description In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, we show that CDK5RAP2 is highly expressed in OSCC and its expression correlates with clinical stage and lymph node metastasis of the disease. The expression of CDK5RAP2 is regulated by the Wnt signaling pathway. Depletion of CDK5RAP2 inhibits the tumorigenesis and migration of OSCC cells and alters the OSCC cancer stem (-like) cell (CSC) signature. Notably, suppression of CDK5RAP2 expression disrupts spindle orientation during mitosis. Collectively, these results identify CDK5RAP2 as a potential CSC marker and reveal a mechanism that controls the CSC population in OSCC.
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spelling pubmed-99222502023-02-13 CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma Shen, Yuehong Chen, Yuling Lin, Yuntao Li, Yicun Liu, Pengfei Zhang, Biru Wang, Yufan Chan, King-Chi Mak, Nai-Ki Kahn, Michael Qi, Robert Z. Yang, Hongyu Cell Death Dis Article In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory protein CDK5RAP2 have not been fully understood. Here, we show that CDK5RAP2 is highly expressed in OSCC and its expression correlates with clinical stage and lymph node metastasis of the disease. The expression of CDK5RAP2 is regulated by the Wnt signaling pathway. Depletion of CDK5RAP2 inhibits the tumorigenesis and migration of OSCC cells and alters the OSCC cancer stem (-like) cell (CSC) signature. Notably, suppression of CDK5RAP2 expression disrupts spindle orientation during mitosis. Collectively, these results identify CDK5RAP2 as a potential CSC marker and reveal a mechanism that controls the CSC population in OSCC. Nature Publishing Group UK 2023-02-11 /pmc/articles/PMC9922250/ /pubmed/36774351 http://dx.doi.org/10.1038/s41419-023-05652-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shen, Yuehong
Chen, Yuling
Lin, Yuntao
Li, Yicun
Liu, Pengfei
Zhang, Biru
Wang, Yufan
Chan, King-Chi
Mak, Nai-Ki
Kahn, Michael
Qi, Robert Z.
Yang, Hongyu
CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title_full CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title_fullStr CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title_full_unstemmed CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title_short CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
title_sort cdk5rap2 is a wnt target gene and promotes stemness and progression of oral squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922250/
https://www.ncbi.nlm.nih.gov/pubmed/36774351
http://dx.doi.org/10.1038/s41419-023-05652-z
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