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Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system

15-prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of oxidizing and degrading PGE2, and related eicosanoids, that support stem cells during tissue repair. Indeed, inhibiting 15-PGDH markedly accelerates tissue repair in multiple org...

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Detalles Bibliográficos
Autores principales:	Huang, Wei, Li, Hongyun, Kiselar, Janna, Fink, Stephen P., Regmi, Sagar, Day, Alexander, Yuan, Yiyuan, Chance, Mark, Ready, Joseph M., Markowitz, Sanford D., Taylor, Derek J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922282/ https://www.ncbi.nlm.nih.gov/pubmed/36774348 http://dx.doi.org/10.1038/s41467-023-36463-7

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