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Methylphenidate-Induced Menorrhagia in Twin Girls

Objective: Methylphenidate, a psychostimulant agent, is used in first-line psychopharmacological treatment in children and adolescents with attention-deficit/hyperactivity disorder. Common side effects associated with methylphenidate use in children and adolescents are insomnia, anorexia, headache,...

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Autores principales: Özdağ, Veysel, Koyuncu, Oğuzhan, Özdemir, Yahya Esad, Tanir, Yaşar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922357/
https://www.ncbi.nlm.nih.gov/pubmed/36817810
http://dx.doi.org/10.18502/ijps.v17i4.10698
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author Özdağ, Veysel
Koyuncu, Oğuzhan
Özdemir, Yahya Esad
Tanir, Yaşar
author_facet Özdağ, Veysel
Koyuncu, Oğuzhan
Özdemir, Yahya Esad
Tanir, Yaşar
author_sort Özdağ, Veysel
collection PubMed
description Objective: Methylphenidate, a psychostimulant agent, is used in first-line psychopharmacological treatment in children and adolescents with attention-deficit/hyperactivity disorder. Common side effects associated with methylphenidate use in children and adolescents are insomnia, anorexia, headache, and nausea. Thrombocytopenia, nasal bleeding and menstrual bleeding disorders are very rarely reported during methylphenidate use. One of the least expected side effects during methylphenidate usage is menorrhagia. Method : In this article, we report methylphenidate monotherapy-induced menorrhagia in two adolescent identical twins. To our knowledge, this is the first report of menorrhagia associated with methylphenidate use in children and adolescents. Results: In both cases, menorrhagia has started after methylphenidate monotherapy and stopped after discontinuation. Other possible etiologies have excluded with clinical and laboratory evaluations. Naranjo Adverse Drug Reaction Probability Score was found 7, indicates probable side effect. Conclusion: Menorrhagia is a rare adverse effect of methylphenidate use and clinicians should be aware of this phenomenon.
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spelling pubmed-99223572023-02-16 Methylphenidate-Induced Menorrhagia in Twin Girls Özdağ, Veysel Koyuncu, Oğuzhan Özdemir, Yahya Esad Tanir, Yaşar Iran J Psychiatry Case Report Objective: Methylphenidate, a psychostimulant agent, is used in first-line psychopharmacological treatment in children and adolescents with attention-deficit/hyperactivity disorder. Common side effects associated with methylphenidate use in children and adolescents are insomnia, anorexia, headache, and nausea. Thrombocytopenia, nasal bleeding and menstrual bleeding disorders are very rarely reported during methylphenidate use. One of the least expected side effects during methylphenidate usage is menorrhagia. Method : In this article, we report methylphenidate monotherapy-induced menorrhagia in two adolescent identical twins. To our knowledge, this is the first report of menorrhagia associated with methylphenidate use in children and adolescents. Results: In both cases, menorrhagia has started after methylphenidate monotherapy and stopped after discontinuation. Other possible etiologies have excluded with clinical and laboratory evaluations. Naranjo Adverse Drug Reaction Probability Score was found 7, indicates probable side effect. Conclusion: Menorrhagia is a rare adverse effect of methylphenidate use and clinicians should be aware of this phenomenon. Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2022-10 /pmc/articles/PMC9922357/ /pubmed/36817810 http://dx.doi.org/10.18502/ijps.v17i4.10698 Text en Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Case Report
Özdağ, Veysel
Koyuncu, Oğuzhan
Özdemir, Yahya Esad
Tanir, Yaşar
Methylphenidate-Induced Menorrhagia in Twin Girls
title Methylphenidate-Induced Menorrhagia in Twin Girls
title_full Methylphenidate-Induced Menorrhagia in Twin Girls
title_fullStr Methylphenidate-Induced Menorrhagia in Twin Girls
title_full_unstemmed Methylphenidate-Induced Menorrhagia in Twin Girls
title_short Methylphenidate-Induced Menorrhagia in Twin Girls
title_sort methylphenidate-induced menorrhagia in twin girls
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922357/
https://www.ncbi.nlm.nih.gov/pubmed/36817810
http://dx.doi.org/10.18502/ijps.v17i4.10698
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