The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword

In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the lo...

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Autores principales: Xu, Yuxiang, Li, Yongjie, Wang, Changqing, Han, Tingting, Liu, Haixuan, Sun, Lin, Hong, Jun, Hashimoto, Makoto, Wei, Jianshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922470/
https://www.ncbi.nlm.nih.gov/pubmed/36774485
http://dx.doi.org/10.1186/s12974-023-02723-y
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author Xu, Yuxiang
Li, Yongjie
Wang, Changqing
Han, Tingting
Liu, Haixuan
Sun, Lin
Hong, Jun
Hashimoto, Makoto
Wei, Jianshe
author_facet Xu, Yuxiang
Li, Yongjie
Wang, Changqing
Han, Tingting
Liu, Haixuan
Sun, Lin
Hong, Jun
Hashimoto, Makoto
Wei, Jianshe
author_sort Xu, Yuxiang
collection PubMed
description In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the loss of dopaminergic neurons. So far, we have mainly focused on the role of the specific class of immune cells in PD while neglecting the impact of interactions among immune cells on the disease. Therefore, this review demonstrates the reciprocal interplays between microglia and T cells and the associated subpopulations through cytokine and chemokine production that impair and/or protect the pathological process of PD. Furthermore, potential targets and models of PD neuroinflammation are highlighted to provide the new ideas/directions for future research.
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spelling pubmed-99224702023-02-13 The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword Xu, Yuxiang Li, Yongjie Wang, Changqing Han, Tingting Liu, Haixuan Sun, Lin Hong, Jun Hashimoto, Makoto Wei, Jianshe J Neuroinflammation Review In Parkinson's disease (PD), neurotoxic microglia, Th1 cells, and Th17 cells are overactivated. Overactivation of these immune cells exacerbates the disease process and leads to the pathological development of pro-inflammatory cytokines, chemokines, and contact-killing compounds, causing the loss of dopaminergic neurons. So far, we have mainly focused on the role of the specific class of immune cells in PD while neglecting the impact of interactions among immune cells on the disease. Therefore, this review demonstrates the reciprocal interplays between microglia and T cells and the associated subpopulations through cytokine and chemokine production that impair and/or protect the pathological process of PD. Furthermore, potential targets and models of PD neuroinflammation are highlighted to provide the new ideas/directions for future research. BioMed Central 2023-02-12 /pmc/articles/PMC9922470/ /pubmed/36774485 http://dx.doi.org/10.1186/s12974-023-02723-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Yuxiang
Li, Yongjie
Wang, Changqing
Han, Tingting
Liu, Haixuan
Sun, Lin
Hong, Jun
Hashimoto, Makoto
Wei, Jianshe
The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title_full The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title_fullStr The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title_full_unstemmed The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title_short The reciprocal interactions between microglia and T cells in Parkinson’s disease: a double-edged sword
title_sort reciprocal interactions between microglia and t cells in parkinson’s disease: a double-edged sword
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922470/
https://www.ncbi.nlm.nih.gov/pubmed/36774485
http://dx.doi.org/10.1186/s12974-023-02723-y
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