HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease

BACKGROUND: HLA-E interaction with inhibitory receptor, NKG2A attenuates NK-mediated cytotoxicity. NKG2A overexpression by SARS-CoV-2 exhausts NK cells function, whereas virus-induced down-regulation of MHC-Ia reduces its derived-leader sequence peptide levels required for proper binding of HLA-E to...

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Detalles Bibliográficos
Autores principales: Hosseini, Ehteramolsadat, Minagar, Arefeh, Ghasemzadeh, Mehran, Arabkhazaeli, Ali, Ghasemzadeh, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922572/
https://www.ncbi.nlm.nih.gov/pubmed/36822912
http://dx.doi.org/10.1016/j.humimm.2023.02.002

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