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Tubridge flow diverter for the treatment of small and medium aneurysms

BACKGROUND: Tubridge flow diverter is a widely used device aimed at reconstructing parent arteries and occluding complex aneurysms in China. The experience of Tubridge in treating small and medium aneurysms is still limited. In this study, we aimed to evaluate the safety and efficacy of the Tubridge...

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Autores principales: Xie, Dajiang, Yang, Heng, Zhao, Li, Ye, Xin, Yang, Shuxu, Gao, Chao, Tian, Yanlong, Ni, Wei, Gu, Yuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922691/
https://www.ncbi.nlm.nih.gov/pubmed/36793490
http://dx.doi.org/10.3389/fneur.2023.1054631
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author Xie, Dajiang
Yang, Heng
Zhao, Li
Ye, Xin
Yang, Shuxu
Gao, Chao
Tian, Yanlong
Ni, Wei
Gu, Yuxiang
author_facet Xie, Dajiang
Yang, Heng
Zhao, Li
Ye, Xin
Yang, Shuxu
Gao, Chao
Tian, Yanlong
Ni, Wei
Gu, Yuxiang
author_sort Xie, Dajiang
collection PubMed
description BACKGROUND: Tubridge flow diverter is a widely used device aimed at reconstructing parent arteries and occluding complex aneurysms in China. The experience of Tubridge in treating small and medium aneurysms is still limited. In this study, we aimed to evaluate the safety and efficacy of the Tubridge flow diverter for the treatment of the two types of aneurysms. METHODS: We reviewed the clinical records of aneurysms treated with a Tubridge flow diverter between 2018 and 2021 in a national cerebrovascular disease center. Cases were divided into small and medium aneurysms according to aneurysm size. The therapeutic process, occlusion rate, and clinical outcome were compared. RESULTS: In total, 57 patients and 77 aneurysms were identified. The patients were divided into two groups: small aneurysms (39 patients, 54 aneurysms) and medium aneurysms (18 patients, 23 aneurysms). There were 19 patients with tandem aneurysms (a total of 39 aneurysms) in the two groups, among which 15 patients (30 aneurysms) were in the small aneurysm group and four patients (nine aneurysms) were in the medium aneurysm group. The results show that the mean maximal diameter/neck in the small and medium aneurysms was 3.68/3.25 and 7.61/6.24 mm, respectively. In total, 57 Tubridge flow diverters were successfully implanted without unfolding failure, and there were six patients with new mild cerebral infarction in the small aneurysm group. The complete occlusion rate on the last angiographic follow-up was achieved in 88.46% of the small aneurysms group and 81.82% of the medium aneurysms group. The complete occlusion rate of patients with tandem aneurysms in the last angiographic follow-up was 86.67% (13/15) of the small aneurysms group and 50% (2/4) of the medium aneurysm group. Intracranial hemorrhage was nonencountered in the two groups. CONCLUSION: Our preliminary experience suggests that the Tubridge flow diverter might be a safe and effective treatment for small and medium aneurysms along the internal carotid artery. Long stents may increase the risk of cerebral infarction. Adequate evidence is required to clarify the definite indications and complications in a multicenter randomized controlled trial with a long-term follow-up.
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spelling pubmed-99226912023-02-14 Tubridge flow diverter for the treatment of small and medium aneurysms Xie, Dajiang Yang, Heng Zhao, Li Ye, Xin Yang, Shuxu Gao, Chao Tian, Yanlong Ni, Wei Gu, Yuxiang Front Neurol Neurology BACKGROUND: Tubridge flow diverter is a widely used device aimed at reconstructing parent arteries and occluding complex aneurysms in China. The experience of Tubridge in treating small and medium aneurysms is still limited. In this study, we aimed to evaluate the safety and efficacy of the Tubridge flow diverter for the treatment of the two types of aneurysms. METHODS: We reviewed the clinical records of aneurysms treated with a Tubridge flow diverter between 2018 and 2021 in a national cerebrovascular disease center. Cases were divided into small and medium aneurysms according to aneurysm size. The therapeutic process, occlusion rate, and clinical outcome were compared. RESULTS: In total, 57 patients and 77 aneurysms were identified. The patients were divided into two groups: small aneurysms (39 patients, 54 aneurysms) and medium aneurysms (18 patients, 23 aneurysms). There were 19 patients with tandem aneurysms (a total of 39 aneurysms) in the two groups, among which 15 patients (30 aneurysms) were in the small aneurysm group and four patients (nine aneurysms) were in the medium aneurysm group. The results show that the mean maximal diameter/neck in the small and medium aneurysms was 3.68/3.25 and 7.61/6.24 mm, respectively. In total, 57 Tubridge flow diverters were successfully implanted without unfolding failure, and there were six patients with new mild cerebral infarction in the small aneurysm group. The complete occlusion rate on the last angiographic follow-up was achieved in 88.46% of the small aneurysms group and 81.82% of the medium aneurysms group. The complete occlusion rate of patients with tandem aneurysms in the last angiographic follow-up was 86.67% (13/15) of the small aneurysms group and 50% (2/4) of the medium aneurysm group. Intracranial hemorrhage was nonencountered in the two groups. CONCLUSION: Our preliminary experience suggests that the Tubridge flow diverter might be a safe and effective treatment for small and medium aneurysms along the internal carotid artery. Long stents may increase the risk of cerebral infarction. Adequate evidence is required to clarify the definite indications and complications in a multicenter randomized controlled trial with a long-term follow-up. Frontiers Media S.A. 2023-01-30 /pmc/articles/PMC9922691/ /pubmed/36793490 http://dx.doi.org/10.3389/fneur.2023.1054631 Text en Copyright © 2023 Xie, Yang, Zhao, Ye, Yang, Gao, Tian, Ni and Gu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Xie, Dajiang
Yang, Heng
Zhao, Li
Ye, Xin
Yang, Shuxu
Gao, Chao
Tian, Yanlong
Ni, Wei
Gu, Yuxiang
Tubridge flow diverter for the treatment of small and medium aneurysms
title Tubridge flow diverter for the treatment of small and medium aneurysms
title_full Tubridge flow diverter for the treatment of small and medium aneurysms
title_fullStr Tubridge flow diverter for the treatment of small and medium aneurysms
title_full_unstemmed Tubridge flow diverter for the treatment of small and medium aneurysms
title_short Tubridge flow diverter for the treatment of small and medium aneurysms
title_sort tubridge flow diverter for the treatment of small and medium aneurysms
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922691/
https://www.ncbi.nlm.nih.gov/pubmed/36793490
http://dx.doi.org/10.3389/fneur.2023.1054631
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