Cargando…
Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus
OBJECTIVE: To quantitatively evaluate the iron deposition and volume changes in deep gray nuclei according to threshold-method of quantitative susceptibility mapping (QSM) acquired by strategically acquired gradient echo (STAGE) sequence, and to analyze the correlation between the magnetic susceptib...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922715/ https://www.ncbi.nlm.nih.gov/pubmed/36793541 http://dx.doi.org/10.3389/fnins.2023.1061156 |
_version_ | 1784887585862057984 |
---|---|
author | Hu, Rui Gao, Bingbing Tian, Shiyun Liu, Yangyingqiu Jiang, Yuhan Li, Wanyao Li, Yuan Song, Qingwei Wang, Weiwei Miao, Yanwei |
author_facet | Hu, Rui Gao, Bingbing Tian, Shiyun Liu, Yangyingqiu Jiang, Yuhan Li, Wanyao Li, Yuan Song, Qingwei Wang, Weiwei Miao, Yanwei |
author_sort | Hu, Rui |
collection | PubMed |
description | OBJECTIVE: To quantitatively evaluate the iron deposition and volume changes in deep gray nuclei according to threshold-method of quantitative susceptibility mapping (QSM) acquired by strategically acquired gradient echo (STAGE) sequence, and to analyze the correlation between the magnetic susceptibility values (MSV) and cognitive scores in type 2 diabetes mellitus (T2DM) patients. METHODS: Twenty-nine patients with T2DM and 24 healthy controls (HC) matched by age and gender were recruited in this prospective study. QSM images were used to evaluate whole-structural volumes (V(wh)), regional magnetic susceptibility values (MSV(RII)), and volumes (V(RII)) in high-iron regions in nine gray nuclei. All QSM data were compared between groups. Receiver operating characteristic (ROC) analysis was used to assess the discriminating ability between groups. The predictive model from single and combined QSM parameters was also established using logistic regression analysis. The correlation between MSV(RII) and cognitive scores was further analyzed. Multiple comparisons of all statistical values were corrected by false discovery rate (FDR). A statistically significant P-value was set at 0.05. RESULTS: Compared with HC group, the MSV(RII) of all gray matter nuclei in T2DM were increased by 5.1–14.8%, with significant differences found in bilateral head of caudate nucleus (HCN), right putamen (PUT), right globus pallidus (GP), and left dentate nucleus (DN) (P < 0.05). The V(wh) of most gray nucleus in T2DM group were decreased by 1.5–16.9% except bilateral subthalamic nucleus (STN). Significant differences were found in bilateral HCN, bilateral red nucleus (RN), and bilateral substantia nigra (SN) (P < 0.05). V(RII) was increased in bilateral GP, bilateral PUT (P < 0.05). V(RII)/V(wh) was also increased in bilateral GP, bilateral PUT, bilateral SN, left HCN and right STN (P < 0.05). Compared with the single QSM parameter, the combined parameter showed the largest area under curve (AUC) of 0.86, with a sensitivity of 87.5% and specificity of 75.9%. The MSV(RII) in the right GP was strongly associated with List A Long-delay free recall (List A LDFR) scores (r = −0.590, P = 0.009). CONCLUSION: In T2DM patients, excessive and heterogeneous iron deposition as well as volume loss occurs in deep gray nuclei. The MSV in high iron regions can better evaluate the distribution of iron, which is related to the decline of cognitive function. |
format | Online Article Text |
id | pubmed-9922715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99227152023-02-14 Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus Hu, Rui Gao, Bingbing Tian, Shiyun Liu, Yangyingqiu Jiang, Yuhan Li, Wanyao Li, Yuan Song, Qingwei Wang, Weiwei Miao, Yanwei Front Neurosci Neuroscience OBJECTIVE: To quantitatively evaluate the iron deposition and volume changes in deep gray nuclei according to threshold-method of quantitative susceptibility mapping (QSM) acquired by strategically acquired gradient echo (STAGE) sequence, and to analyze the correlation between the magnetic susceptibility values (MSV) and cognitive scores in type 2 diabetes mellitus (T2DM) patients. METHODS: Twenty-nine patients with T2DM and 24 healthy controls (HC) matched by age and gender were recruited in this prospective study. QSM images were used to evaluate whole-structural volumes (V(wh)), regional magnetic susceptibility values (MSV(RII)), and volumes (V(RII)) in high-iron regions in nine gray nuclei. All QSM data were compared between groups. Receiver operating characteristic (ROC) analysis was used to assess the discriminating ability between groups. The predictive model from single and combined QSM parameters was also established using logistic regression analysis. The correlation between MSV(RII) and cognitive scores was further analyzed. Multiple comparisons of all statistical values were corrected by false discovery rate (FDR). A statistically significant P-value was set at 0.05. RESULTS: Compared with HC group, the MSV(RII) of all gray matter nuclei in T2DM were increased by 5.1–14.8%, with significant differences found in bilateral head of caudate nucleus (HCN), right putamen (PUT), right globus pallidus (GP), and left dentate nucleus (DN) (P < 0.05). The V(wh) of most gray nucleus in T2DM group were decreased by 1.5–16.9% except bilateral subthalamic nucleus (STN). Significant differences were found in bilateral HCN, bilateral red nucleus (RN), and bilateral substantia nigra (SN) (P < 0.05). V(RII) was increased in bilateral GP, bilateral PUT (P < 0.05). V(RII)/V(wh) was also increased in bilateral GP, bilateral PUT, bilateral SN, left HCN and right STN (P < 0.05). Compared with the single QSM parameter, the combined parameter showed the largest area under curve (AUC) of 0.86, with a sensitivity of 87.5% and specificity of 75.9%. The MSV(RII) in the right GP was strongly associated with List A Long-delay free recall (List A LDFR) scores (r = −0.590, P = 0.009). CONCLUSION: In T2DM patients, excessive and heterogeneous iron deposition as well as volume loss occurs in deep gray nuclei. The MSV in high iron regions can better evaluate the distribution of iron, which is related to the decline of cognitive function. Frontiers Media S.A. 2023-01-30 /pmc/articles/PMC9922715/ /pubmed/36793541 http://dx.doi.org/10.3389/fnins.2023.1061156 Text en Copyright © 2023 Hu, Gao, Tian, Liu, Jiang, Li, Li, Song, Wang and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Hu, Rui Gao, Bingbing Tian, Shiyun Liu, Yangyingqiu Jiang, Yuhan Li, Wanyao Li, Yuan Song, Qingwei Wang, Weiwei Miao, Yanwei Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title_full | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title_fullStr | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title_full_unstemmed | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title_short | Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
title_sort | regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922715/ https://www.ncbi.nlm.nih.gov/pubmed/36793541 http://dx.doi.org/10.3389/fnins.2023.1061156 |
work_keys_str_mv | AT hurui regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT gaobingbing regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT tianshiyun regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT liuyangyingqiu regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT jiangyuhan regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT liwanyao regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT liyuan regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT songqingwei regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT wangweiwei regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus AT miaoyanwei regionalhighirondepositiononquantitativesusceptibilitymappingcorrelateswithcognitivedeclineintype2diabetesmellitus |