Cargando…
Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences
BACKGROUND: Lipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, th...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922762/ https://www.ncbi.nlm.nih.gov/pubmed/36793942 http://dx.doi.org/10.3389/fpsyt.2023.1101865 |
_version_ | 1784887597568360448 |
---|---|
author | Zhu, Quanfeng Zheng, Yali Lang, XiaoE Fu, Zhengchuang Zhang, Peng Jiang, Guojun Zhang, Xiangyang |
author_facet | Zhu, Quanfeng Zheng, Yali Lang, XiaoE Fu, Zhengchuang Zhang, Peng Jiang, Guojun Zhang, Xiangyang |
author_sort | Zhu, Quanfeng |
collection | PubMed |
description | BACKGROUND: Lipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naïve (FEDN) MDD patients with dysglycemia were examined according to sex. METHODS: One thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected. RESULTS: The prevalence of abnormal lipid metabolism in both male and female MDD patients with abnormal glucose metabolism was higher than that in patients without abnormal glucose metabolism. Among male MDD patients with abnormal glucose metabolism, TC was positively correlated with HAMD score, TSH and TgAb levels, but negatively correlated with PANSS positive subscale scores. LDL-C was positively correlated with TSH and BMI, but negatively correlated with PANSS positive subscale scores. HDL-C was negatively correlated with TSH levels. Among females, TC was positively correlated with HAMD score, TSH, and BMI, but negatively correlated with PANSS positive subscale score. LDL-C was positively correlated with HADM score and negatively correlated with FT3 level. HDL-C was negatively correlated with TSH and BMI levels. CONCLUSION: There are sex differences in the correlated factors of lipid markers in MDD patients with impaired glucose. |
format | Online Article Text |
id | pubmed-9922762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99227622023-02-14 Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences Zhu, Quanfeng Zheng, Yali Lang, XiaoE Fu, Zhengchuang Zhang, Peng Jiang, Guojun Zhang, Xiangyang Front Psychiatry Psychiatry BACKGROUND: Lipid metabolism is associated with glucose metabolism, but whether there are variations between sexes in risk factors and prevalence of abnormal lipid metabolism in major depressive disorder (MDD) patients with glucose metabolism abnormalities remains ambiguous. In the present study, the frequency and risk factors of dyslipidemia in first-episode and drug-naïve (FEDN) MDD patients with dysglycemia were examined according to sex. METHODS: One thousand seven hundred and eighteen FEDN MDD patients were recruited and their demographic data, clinical data, various biochemical indicators and scale assessment scores including 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were collected. RESULTS: The prevalence of abnormal lipid metabolism in both male and female MDD patients with abnormal glucose metabolism was higher than that in patients without abnormal glucose metabolism. Among male MDD patients with abnormal glucose metabolism, TC was positively correlated with HAMD score, TSH and TgAb levels, but negatively correlated with PANSS positive subscale scores. LDL-C was positively correlated with TSH and BMI, but negatively correlated with PANSS positive subscale scores. HDL-C was negatively correlated with TSH levels. Among females, TC was positively correlated with HAMD score, TSH, and BMI, but negatively correlated with PANSS positive subscale score. LDL-C was positively correlated with HADM score and negatively correlated with FT3 level. HDL-C was negatively correlated with TSH and BMI levels. CONCLUSION: There are sex differences in the correlated factors of lipid markers in MDD patients with impaired glucose. Frontiers Media S.A. 2023-01-30 /pmc/articles/PMC9922762/ /pubmed/36793942 http://dx.doi.org/10.3389/fpsyt.2023.1101865 Text en Copyright © 2023 Zhu, Zheng, Lang, Fu, Zhang, Jiang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhu, Quanfeng Zheng, Yali Lang, XiaoE Fu, Zhengchuang Zhang, Peng Jiang, Guojun Zhang, Xiangyang Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title | Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title_full | Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title_fullStr | Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title_full_unstemmed | Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title_short | Prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: Sex differences |
title_sort | prevalence and correlates of dyslipidemia in first-episode and drug-naïve major depressive disorder patients with comorbid abnormal glucose metabolism: sex differences |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922762/ https://www.ncbi.nlm.nih.gov/pubmed/36793942 http://dx.doi.org/10.3389/fpsyt.2023.1101865 |
work_keys_str_mv | AT zhuquanfeng prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT zhengyali prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT langxiaoe prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT fuzhengchuang prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT zhangpeng prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT jiangguojun prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences AT zhangxiangyang prevalenceandcorrelatesofdyslipidemiainfirstepisodeanddrugnaivemajordepressivedisorderpatientswithcomorbidabnormalglucosemetabolismsexdifferences |