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The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia

BACKGROUND: Our previous study has shown the cingulate cortex abnormalities in first-episode drug naïve (FEDN) schizophrenia patients with comorbid depressive symptoms. However, it remains largely unknown whether antipsychotics may induce morphometric change in cingulate cortex and its relationship...

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Autores principales: Shen, Haoran, Ge, Likun, Cao, Bo, Wei, Gao-Xia, Zhang, Xiangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asociacion Espanola de Psicologia Conductual 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922813/
https://www.ncbi.nlm.nih.gov/pubmed/36793339
http://dx.doi.org/10.1016/j.ijchp.2023.100372
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author Shen, Haoran
Ge, Likun
Cao, Bo
Wei, Gao-Xia
Zhang, Xiangyang
author_facet Shen, Haoran
Ge, Likun
Cao, Bo
Wei, Gao-Xia
Zhang, Xiangyang
author_sort Shen, Haoran
collection PubMed
description BACKGROUND: Our previous study has shown the cingulate cortex abnormalities in first-episode drug naïve (FEDN) schizophrenia patients with comorbid depressive symptoms. However, it remains largely unknown whether antipsychotics may induce morphometric change in cingulate cortex and its relationship with depressive symptoms. The purpose of this study was to further clarify the important role of cingulate cortex in the treatment on depressive symptoms in FEDN schizophrenia patients. METHOD: In this study, 42 FEDN schizophrenia patients were assigned into depressed patients group (DP, n = 24) and non-depressed patients group (NDP, n = 18) measured by the 24-item Hamilton Depression Rating Scale (HAMD). Clinical assessments and anatomical images were obtained from all patients before and after 12-week treatment with risperidone. RESULTS: Although risperidone alleviated psychotic symptoms in all patients, depressive symptoms were decreased only in DP. Significant group by time interaction effects were found in the right rostral anterior cingulate cortex (rACC) and other subcortical regions in the left hemisphere. After risperidone treatment, the right rACC were increased in DP. Further, the increasing volume of right rACC was negatively associated with improvement in depressive symptoms. CONCLUSION: These findings suggested that the abnormality of the rACC is the typical characteristics in schizophrenia with depressive symptoms. It's likely key region contributing to the neural mechanisms underlying the effects of risperidone treatment on depressive symptoms in schizophrenia.
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spelling pubmed-99228132023-02-14 The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia Shen, Haoran Ge, Likun Cao, Bo Wei, Gao-Xia Zhang, Xiangyang Int J Clin Health Psychol Original Article BACKGROUND: Our previous study has shown the cingulate cortex abnormalities in first-episode drug naïve (FEDN) schizophrenia patients with comorbid depressive symptoms. However, it remains largely unknown whether antipsychotics may induce morphometric change in cingulate cortex and its relationship with depressive symptoms. The purpose of this study was to further clarify the important role of cingulate cortex in the treatment on depressive symptoms in FEDN schizophrenia patients. METHOD: In this study, 42 FEDN schizophrenia patients were assigned into depressed patients group (DP, n = 24) and non-depressed patients group (NDP, n = 18) measured by the 24-item Hamilton Depression Rating Scale (HAMD). Clinical assessments and anatomical images were obtained from all patients before and after 12-week treatment with risperidone. RESULTS: Although risperidone alleviated psychotic symptoms in all patients, depressive symptoms were decreased only in DP. Significant group by time interaction effects were found in the right rostral anterior cingulate cortex (rACC) and other subcortical regions in the left hemisphere. After risperidone treatment, the right rACC were increased in DP. Further, the increasing volume of right rACC was negatively associated with improvement in depressive symptoms. CONCLUSION: These findings suggested that the abnormality of the rACC is the typical characteristics in schizophrenia with depressive symptoms. It's likely key region contributing to the neural mechanisms underlying the effects of risperidone treatment on depressive symptoms in schizophrenia. Asociacion Espanola de Psicologia Conductual 2023 2023-01-28 /pmc/articles/PMC9922813/ /pubmed/36793339 http://dx.doi.org/10.1016/j.ijchp.2023.100372 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Shen, Haoran
Ge, Likun
Cao, Bo
Wei, Gao-Xia
Zhang, Xiangyang
The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title_full The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title_fullStr The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title_full_unstemmed The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title_short The contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
title_sort contribution of the cingulate cortex: treating depressive symptoms in first-episode drug naïve schizophrenia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922813/
https://www.ncbi.nlm.nih.gov/pubmed/36793339
http://dx.doi.org/10.1016/j.ijchp.2023.100372
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