Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry

G proteins and G protein–coupled receptors activate a diverse array of signal transduction pathways that promote cell growth and survival. Indeed, hot spot–activating mutations in GNAQ/GNA11, encoding Gαq proteins, are known to be driver oncogenes in uveal melanoma (UM), for which there are limited...

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Detalles Bibliográficos
Autores principales: Arang, Nadia, Lubrano, Simone, Rigiracciolo, Damiano Cosimo, Nachmanson, Daniela, Lippman, Scott M., Mali, Prashant, Harismendy, Olivier, Gutkind, J. Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922814/
https://www.ncbi.nlm.nih.gov/pubmed/36596361
http://dx.doi.org/10.1016/j.jbc.2022.102866

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