Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins

Aurora kinases (AURKs) are mitotic kinases important for regulating cell cycle progression. Small-molecule inhibitors of AURK have shown promising antitumor effects in multiple cancers; however, the utility of these inhibitors as inducers of cancer cell death has thus far been limited. Here, we exam...

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Detalles Bibliográficos
Autores principales: Li, Jian, Chen, Cheng-Hsun, O’Neill, Katelyn L., Fousek-Schuller, Valerie J., Black, Adrian R., Black, Jennifer D., Zhang, Jingjing, Luo, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922828/
https://www.ncbi.nlm.nih.gov/pubmed/36621626
http://dx.doi.org/10.1016/j.jbc.2023.102875

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