Transcriptome analysis reveals effects of leukemogenic SHP2 mutations in biosynthesis of amino acids signaling

Gain-of-function mutations of SHP2, especially D61Y and E76K, lead to the development of neoplasms in hematopoietic cells. Previously, we found that SHP2-D61Y and -E76K confer HCD-57 cells cytokine-independent survival and proliferation via activation of MAPK pathway. Metabolic reprogramming is like...

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Detalles Bibliográficos
Autores principales: Zhao, Yuming, Chang, Zhiguang, Hu, Bingbing, Zhang, Qi, Zhang, Dengyang, He, Chunxiao, Guo, Yao, Peng, Zhiyong, Chen, Chun, Chen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922838/
https://www.ncbi.nlm.nih.gov/pubmed/36793607
http://dx.doi.org/10.3389/fonc.2023.1090542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922838/
https://www.ncbi.nlm.nih.gov/pubmed/36793607
http://dx.doi.org/10.3389/fonc.2023.1090542

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