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Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review

Cervical lymphadenopathy as the initial presentation of metastatic prostate cancer is particularly uncommon, and easily misdiagnosed. In the current study, we describe five cases of metastatic prostate cancer in our hospital that presented with cervical lymphadenopathy as an initial symptom. The dia...

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Autores principales: Liu, Yangyang, Dai, Zhihong, Hao, Jiange, Wang, Liang, Liu, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922865/
https://www.ncbi.nlm.nih.gov/pubmed/36793314
http://dx.doi.org/10.3389/fsurg.2023.1081951
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author Liu, Yangyang
Dai, Zhihong
Hao, Jiange
Wang, Liang
Liu, Zhiyu
author_facet Liu, Yangyang
Dai, Zhihong
Hao, Jiange
Wang, Liang
Liu, Zhiyu
author_sort Liu, Yangyang
collection PubMed
description Cervical lymphadenopathy as the initial presentation of metastatic prostate cancer is particularly uncommon, and easily misdiagnosed. In the current study, we describe five cases of metastatic prostate cancer in our hospital that presented with cervical lymphadenopathy as an initial symptom. The diagnosis was confirmed by needle biopsy of the suspicious lymph nodes and the serum prostate specific antigen (PSA) levels of all patients exceeded 100 ng/ml. The five patients were treated with hormonal therapy; four received traditional hormonal therapy, including bicalutamide and goserelin; one patient received hormonal therapy that included abiraterone and goserelin. Case 1 developed into castration-resistant prostate cancer (CRPC) after 7 months and died after 12 months. Case 2 rejected regular hormonal therapy for personal reasons and died 6 months after the initial diagnosis. Case 3 was still alive at the time of writing. Case 4 was administered with abiraterone, prednisolone and goserelin; the treatment was effective and the patient has remained symptom-free for the last 24 months. Case 5 was treated with hormonal and chemotherapy but died 8 months after diagnosis. In conclusion, any elderly male presenting with cervical lymphadenopathy should be considered the possibility of prostate cancer, especially when the needle biopsy reveals adenocarcinoma. The prognosis for patients presented with cervical lymphadenopathy as the initial presentation is usually poor. Hormone therapy based on abiraterone may yield a better response in such cases.
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spelling pubmed-99228652023-02-14 Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review Liu, Yangyang Dai, Zhihong Hao, Jiange Wang, Liang Liu, Zhiyu Front Surg Surgery Cervical lymphadenopathy as the initial presentation of metastatic prostate cancer is particularly uncommon, and easily misdiagnosed. In the current study, we describe five cases of metastatic prostate cancer in our hospital that presented with cervical lymphadenopathy as an initial symptom. The diagnosis was confirmed by needle biopsy of the suspicious lymph nodes and the serum prostate specific antigen (PSA) levels of all patients exceeded 100 ng/ml. The five patients were treated with hormonal therapy; four received traditional hormonal therapy, including bicalutamide and goserelin; one patient received hormonal therapy that included abiraterone and goserelin. Case 1 developed into castration-resistant prostate cancer (CRPC) after 7 months and died after 12 months. Case 2 rejected regular hormonal therapy for personal reasons and died 6 months after the initial diagnosis. Case 3 was still alive at the time of writing. Case 4 was administered with abiraterone, prednisolone and goserelin; the treatment was effective and the patient has remained symptom-free for the last 24 months. Case 5 was treated with hormonal and chemotherapy but died 8 months after diagnosis. In conclusion, any elderly male presenting with cervical lymphadenopathy should be considered the possibility of prostate cancer, especially when the needle biopsy reveals adenocarcinoma. The prognosis for patients presented with cervical lymphadenopathy as the initial presentation is usually poor. Hormone therapy based on abiraterone may yield a better response in such cases. Frontiers Media S.A. 2023-01-30 /pmc/articles/PMC9922865/ /pubmed/36793314 http://dx.doi.org/10.3389/fsurg.2023.1081951 Text en © 2023 Liu, Dai, Hao, Wang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Liu, Yangyang
Dai, Zhihong
Hao, Jiange
Wang, Liang
Liu, Zhiyu
Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title_full Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title_fullStr Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title_full_unstemmed Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title_short Cervical lymphadenopathy as initial presentation of metastatic prostate cancer: A retrospective study of five cases and literature review
title_sort cervical lymphadenopathy as initial presentation of metastatic prostate cancer: a retrospective study of five cases and literature review
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922865/
https://www.ncbi.nlm.nih.gov/pubmed/36793314
http://dx.doi.org/10.3389/fsurg.2023.1081951
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