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Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis

OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC p...

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Autores principales: Yu, Xiaoyun, Shi, Yongmei, Yuan, Rongtao, Chen, Zhenggang, Dong, Quanjiang, Han, Linzi, Wang, Lili, Zhou, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922960/
https://www.ncbi.nlm.nih.gov/pubmed/36793959
http://dx.doi.org/10.1016/j.heliyon.2023.e13198
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author Yu, Xiaoyun
Shi, Yongmei
Yuan, Rongtao
Chen, Zhenggang
Dong, Quanjiang
Han, Linzi
Wang, Lili
Zhou, Jianhua
author_facet Yu, Xiaoyun
Shi, Yongmei
Yuan, Rongtao
Chen, Zhenggang
Dong, Quanjiang
Han, Linzi
Wang, Lili
Zhou, Jianhua
author_sort Yu, Xiaoyun
collection PubMed
description OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model. RESULTS: A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues. At the phylum level, enrichment of Fusobacteria but depletion in Actinobacteria and Firmicutes in the oral microbiome was demonstrated in both categories of studies. At the genus level, Fusobacterium showed an increased abundance in OSCC patients (SMD = 0.65, 95% CI: 0.43–0.87, Z = 5.809, P = 0.000) and in cancerous tissues (SMD = 0.54, 95% CI: 0.36–0.72, Z = 5.785, P = 0.000). The abundance of Streptococcus was decreased in OSCC (SMD = −0.46, 95% CI: −0.88−0.04, Z = −2.146, P = 0.032) and in cancerous tissues (SMD = −0.45, 95% CI: −0.78–0.13, Z = −2.726, P = 0.006). CONCLUSIONS: Disturbances in the interactions between enriched Fusobacterium and depleted Streptococcus may participate in or prompt the occurrence and development of OSCC and could be potential biomarkers for detection of OSCC.
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spelling pubmed-99229602023-02-14 Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis Yu, Xiaoyun Shi, Yongmei Yuan, Rongtao Chen, Zhenggang Dong, Quanjiang Han, Linzi Wang, Lili Zhou, Jianhua Heliyon Review Article OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model. RESULTS: A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues. At the phylum level, enrichment of Fusobacteria but depletion in Actinobacteria and Firmicutes in the oral microbiome was demonstrated in both categories of studies. At the genus level, Fusobacterium showed an increased abundance in OSCC patients (SMD = 0.65, 95% CI: 0.43–0.87, Z = 5.809, P = 0.000) and in cancerous tissues (SMD = 0.54, 95% CI: 0.36–0.72, Z = 5.785, P = 0.000). The abundance of Streptococcus was decreased in OSCC (SMD = −0.46, 95% CI: −0.88−0.04, Z = −2.146, P = 0.032) and in cancerous tissues (SMD = −0.45, 95% CI: −0.78–0.13, Z = −2.726, P = 0.006). CONCLUSIONS: Disturbances in the interactions between enriched Fusobacterium and depleted Streptococcus may participate in or prompt the occurrence and development of OSCC and could be potential biomarkers for detection of OSCC. Elsevier 2023-01-24 /pmc/articles/PMC9922960/ /pubmed/36793959 http://dx.doi.org/10.1016/j.heliyon.2023.e13198 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Yu, Xiaoyun
Shi, Yongmei
Yuan, Rongtao
Chen, Zhenggang
Dong, Quanjiang
Han, Linzi
Wang, Lili
Zhou, Jianhua
Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title_full Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title_fullStr Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title_full_unstemmed Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title_short Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
title_sort microbial dysbiosis in oral squamous cell carcinoma: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922960/
https://www.ncbi.nlm.nih.gov/pubmed/36793959
http://dx.doi.org/10.1016/j.heliyon.2023.e13198
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