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Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis
OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922960/ https://www.ncbi.nlm.nih.gov/pubmed/36793959 http://dx.doi.org/10.1016/j.heliyon.2023.e13198 |
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author | Yu, Xiaoyun Shi, Yongmei Yuan, Rongtao Chen, Zhenggang Dong, Quanjiang Han, Linzi Wang, Lili Zhou, Jianhua |
author_facet | Yu, Xiaoyun Shi, Yongmei Yuan, Rongtao Chen, Zhenggang Dong, Quanjiang Han, Linzi Wang, Lili Zhou, Jianhua |
author_sort | Yu, Xiaoyun |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model. RESULTS: A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues. At the phylum level, enrichment of Fusobacteria but depletion in Actinobacteria and Firmicutes in the oral microbiome was demonstrated in both categories of studies. At the genus level, Fusobacterium showed an increased abundance in OSCC patients (SMD = 0.65, 95% CI: 0.43–0.87, Z = 5.809, P = 0.000) and in cancerous tissues (SMD = 0.54, 95% CI: 0.36–0.72, Z = 5.785, P = 0.000). The abundance of Streptococcus was decreased in OSCC (SMD = −0.46, 95% CI: −0.88−0.04, Z = −2.146, P = 0.032) and in cancerous tissues (SMD = −0.45, 95% CI: −0.78–0.13, Z = −2.726, P = 0.006). CONCLUSIONS: Disturbances in the interactions between enriched Fusobacterium and depleted Streptococcus may participate in or prompt the occurrence and development of OSCC and could be potential biomarkers for detection of OSCC. |
format | Online Article Text |
id | pubmed-9922960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99229602023-02-14 Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis Yu, Xiaoyun Shi, Yongmei Yuan, Rongtao Chen, Zhenggang Dong, Quanjiang Han, Linzi Wang, Lili Zhou, Jianhua Heliyon Review Article OBJECTIVE: The aim of this study was to summarize previously published data and assess the alterations in the composition of the oral microbiome in OSCC using a systematic review and meta-analysis. DESIGN: Electronic databases were systematically searched for studies on the oral microbiome in OSCC published before December 2021. Qualitative assessments of compositional variations at the phylum level were performed. The meta-analysis on abundance changes of bacteria genera was performed via a random-effects model. RESULTS: A total of 18 studies involving 1056 participants were included. They consisted of two categories of studies: 1) case-control studies (n = 9); 2) nine studies that compared the oral microbiome between cancerous tissues and paired paracancerous tissues. At the phylum level, enrichment of Fusobacteria but depletion in Actinobacteria and Firmicutes in the oral microbiome was demonstrated in both categories of studies. At the genus level, Fusobacterium showed an increased abundance in OSCC patients (SMD = 0.65, 95% CI: 0.43–0.87, Z = 5.809, P = 0.000) and in cancerous tissues (SMD = 0.54, 95% CI: 0.36–0.72, Z = 5.785, P = 0.000). The abundance of Streptococcus was decreased in OSCC (SMD = −0.46, 95% CI: −0.88−0.04, Z = −2.146, P = 0.032) and in cancerous tissues (SMD = −0.45, 95% CI: −0.78–0.13, Z = −2.726, P = 0.006). CONCLUSIONS: Disturbances in the interactions between enriched Fusobacterium and depleted Streptococcus may participate in or prompt the occurrence and development of OSCC and could be potential biomarkers for detection of OSCC. Elsevier 2023-01-24 /pmc/articles/PMC9922960/ /pubmed/36793959 http://dx.doi.org/10.1016/j.heliyon.2023.e13198 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Yu, Xiaoyun Shi, Yongmei Yuan, Rongtao Chen, Zhenggang Dong, Quanjiang Han, Linzi Wang, Lili Zhou, Jianhua Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title | Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title_full | Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title_fullStr | Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title_full_unstemmed | Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title_short | Microbial dysbiosis in oral squamous cell carcinoma: A systematic review and meta-analysis |
title_sort | microbial dysbiosis in oral squamous cell carcinoma: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922960/ https://www.ncbi.nlm.nih.gov/pubmed/36793959 http://dx.doi.org/10.1016/j.heliyon.2023.e13198 |
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