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Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hep...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922962/ https://www.ncbi.nlm.nih.gov/pubmed/36794122 http://dx.doi.org/10.1016/j.pacs.2023.100454 |
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author | Fasoula, Nikolina-Alexia Karlas, Angelos Prokopchuk, Olga Katsouli, Nikoletta Bariotakis, Michail Liapis, Evangelos Goetz, Anna Kallmayer, Michael Reber, Josefine Novotny, Alexander Friess, Helmut Ringelhan, Marc Schmid, Roland Eckstein, Hans-Henning Hofmann, Susanna Ntziachristos, Vasilis |
author_facet | Fasoula, Nikolina-Alexia Karlas, Angelos Prokopchuk, Olga Katsouli, Nikoletta Bariotakis, Michail Liapis, Evangelos Goetz, Anna Kallmayer, Michael Reber, Josefine Novotny, Alexander Friess, Helmut Ringelhan, Marc Schmid, Roland Eckstein, Hans-Henning Hofmann, Susanna Ntziachristos, Vasilis |
author_sort | Fasoula, Nikolina-Alexia |
collection | PubMed |
description | Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies. |
format | Online Article Text |
id | pubmed-9922962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99229622023-02-14 Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis Fasoula, Nikolina-Alexia Karlas, Angelos Prokopchuk, Olga Katsouli, Nikoletta Bariotakis, Michail Liapis, Evangelos Goetz, Anna Kallmayer, Michael Reber, Josefine Novotny, Alexander Friess, Helmut Ringelhan, Marc Schmid, Roland Eckstein, Hans-Henning Hofmann, Susanna Ntziachristos, Vasilis Photoacoustics Research Article Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies. Elsevier 2023-01-20 /pmc/articles/PMC9922962/ /pubmed/36794122 http://dx.doi.org/10.1016/j.pacs.2023.100454 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Fasoula, Nikolina-Alexia Karlas, Angelos Prokopchuk, Olga Katsouli, Nikoletta Bariotakis, Michail Liapis, Evangelos Goetz, Anna Kallmayer, Michael Reber, Josefine Novotny, Alexander Friess, Helmut Ringelhan, Marc Schmid, Roland Eckstein, Hans-Henning Hofmann, Susanna Ntziachristos, Vasilis Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title | Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title_full | Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title_fullStr | Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title_full_unstemmed | Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title_short | Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
title_sort | non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922962/ https://www.ncbi.nlm.nih.gov/pubmed/36794122 http://dx.doi.org/10.1016/j.pacs.2023.100454 |
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