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Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis

Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hep...

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Autores principales: Fasoula, Nikolina-Alexia, Karlas, Angelos, Prokopchuk, Olga, Katsouli, Nikoletta, Bariotakis, Michail, Liapis, Evangelos, Goetz, Anna, Kallmayer, Michael, Reber, Josefine, Novotny, Alexander, Friess, Helmut, Ringelhan, Marc, Schmid, Roland, Eckstein, Hans-Henning, Hofmann, Susanna, Ntziachristos, Vasilis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922962/
https://www.ncbi.nlm.nih.gov/pubmed/36794122
http://dx.doi.org/10.1016/j.pacs.2023.100454
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author Fasoula, Nikolina-Alexia
Karlas, Angelos
Prokopchuk, Olga
Katsouli, Nikoletta
Bariotakis, Michail
Liapis, Evangelos
Goetz, Anna
Kallmayer, Michael
Reber, Josefine
Novotny, Alexander
Friess, Helmut
Ringelhan, Marc
Schmid, Roland
Eckstein, Hans-Henning
Hofmann, Susanna
Ntziachristos, Vasilis
author_facet Fasoula, Nikolina-Alexia
Karlas, Angelos
Prokopchuk, Olga
Katsouli, Nikoletta
Bariotakis, Michail
Liapis, Evangelos
Goetz, Anna
Kallmayer, Michael
Reber, Josefine
Novotny, Alexander
Friess, Helmut
Ringelhan, Marc
Schmid, Roland
Eckstein, Hans-Henning
Hofmann, Susanna
Ntziachristos, Vasilis
author_sort Fasoula, Nikolina-Alexia
collection PubMed
description Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies.
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spelling pubmed-99229622023-02-14 Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis Fasoula, Nikolina-Alexia Karlas, Angelos Prokopchuk, Olga Katsouli, Nikoletta Bariotakis, Michail Liapis, Evangelos Goetz, Anna Kallmayer, Michael Reber, Josefine Novotny, Alexander Friess, Helmut Ringelhan, Marc Schmid, Roland Eckstein, Hans-Henning Hofmann, Susanna Ntziachristos, Vasilis Photoacoustics Research Article Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of liver lipid content to enable non-invasive characterization of hepatic steatosis by analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, we apply MSOT to measure liver and surrounding tissues in five patients with liver steatosis and five healthy volunteers, revealing significantly higher absorptions at 930 nm in the patients, while no significant difference was observed in the subcutaneous adipose tissue of the two groups. We further corroborated the human observations with corresponding MSOT measurements in high fat diet (HFD) - and regular chow diet (CD)-fed mice. This study introduces MSOT as a potential non-invasive and portable technique for detecting/monitoring hepatic steatosis in clinical settings, providing justification for larger studies. Elsevier 2023-01-20 /pmc/articles/PMC9922962/ /pubmed/36794122 http://dx.doi.org/10.1016/j.pacs.2023.100454 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Fasoula, Nikolina-Alexia
Karlas, Angelos
Prokopchuk, Olga
Katsouli, Nikoletta
Bariotakis, Michail
Liapis, Evangelos
Goetz, Anna
Kallmayer, Michael
Reber, Josefine
Novotny, Alexander
Friess, Helmut
Ringelhan, Marc
Schmid, Roland
Eckstein, Hans-Henning
Hofmann, Susanna
Ntziachristos, Vasilis
Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title_full Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title_fullStr Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title_full_unstemmed Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title_short Non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
title_sort non-invasive multispectral optoacoustic tomography resolves intrahepatic lipids in patients with hepatic steatosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922962/
https://www.ncbi.nlm.nih.gov/pubmed/36794122
http://dx.doi.org/10.1016/j.pacs.2023.100454
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