Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid

Introduction: Cytochrome P450 (CYP) 3A4 is a major drug metabolizing enzyme for corticosteroids (CS). Epimedium has been used for asthma and variety of inflammatory conditions with or without CS. It is unknown whether epimedium has an effect on CYP 3A4 and how it interacts with CS. We sought to dete...

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Detalles Bibliográficos
Autores principales: Li, Ke, Yu, Xiu-Hua, Maskey, Anish R., Musa, Ibrahim, Wang, Zhen-Zheng, Garcia, Victor, Guo, Austin, Yang, Nan, Srivastava, Kamal, Dunkin, David, Li, Jun-Xiong, Guo, Longgang, Cheng, Yung-Chi, Yuan, Haoliang, Tiwari, Raj, Li, Xiu-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922998/
https://www.ncbi.nlm.nih.gov/pubmed/36793921
http://dx.doi.org/10.3389/fphar.2022.1042756

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