Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndrome

BACKGROUND AND AIMS: Tumor immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins is often used to guide germline genetic testing and variant classification for patients with suspected Lynch syndrome. This analysis examined the spectrum of germline findings in a cohort of individua...

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Detalles Bibliográficos
Autores principales: Pan, Shujuan, Cox, Hannah, Willmott, Jamie, Mundt, Erin, Gorringe, Heidi, Landon, Michelle, Bowles, Karla R., Coffee, Bradford, Roa, Benjamin B., Mancini-DiNardo, Debora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923021/
https://www.ncbi.nlm.nih.gov/pubmed/36793599
http://dx.doi.org/10.3389/fonc.2023.1069467

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