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Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial
OBJECTIVE: To design and conduct the effectiveness of Ketamine vs Dexmedetomidine in children’s sedation at emergency department (ED). METHODS: This randomized clinical trial study was carried out at the two trauma centers in Mashhad, Iran. The patients were divided into two groups by means of a ran...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shiraz University of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923034/ https://www.ncbi.nlm.nih.gov/pubmed/36818052 http://dx.doi.org/10.30476/beat.2022.95647.1366 |
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author | Rezvani Kakhki, Behrang Fugerdi, Melika Abbasishaye, Zahra Feyz Dysfani, Hamideh Vafadar Moradi, Elnaz |
author_facet | Rezvani Kakhki, Behrang Fugerdi, Melika Abbasishaye, Zahra Feyz Dysfani, Hamideh Vafadar Moradi, Elnaz |
author_sort | Rezvani Kakhki, Behrang |
collection | PubMed |
description | OBJECTIVE: To design and conduct the effectiveness of Ketamine vs Dexmedetomidine in children’s sedation at emergency department (ED). METHODS: This randomized clinical trial study was carried out at the two trauma centers in Mashhad, Iran. The patients were divided into two groups by means of a random numbers table to be treated with Ketamine (N=20) or Dexmedetomidine (N=20). Their demographic information and sedation times of drugs were collected and analyzed. RESULTS: In general, sedation time was significantly higher in the ketamine group, 14.35 minutes (IQR:9.82-19) than in the dexmedetomidine group, 9.7 minutes (8.35-14.23) (p=0.023). Time of injection to complete anesthesia was 45.25 (IQR:30-58) and 72 (IQR:60.25-82) minutes in ketamine and dexmedetomidine groups, respectively (p<0.01). In the case of recovery, grade 4 of the Ramsey scale was statistically more prevalent in dexmedetomidine (45%) than in the ketamine group (p=0.0001). CONCLUSION: This study demonstrated that dexmedetomidine could be used in cases where a shorter sedation time is vital. Ketamine could be a better choice where full recovery time (from injection) matters most. Clinical Trial registration code: IR.MUMS.fm.REC.1396.534. |
format | Online Article Text |
id | pubmed-9923034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Shiraz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-99230342023-02-16 Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial Rezvani Kakhki, Behrang Fugerdi, Melika Abbasishaye, Zahra Feyz Dysfani, Hamideh Vafadar Moradi, Elnaz Bull Emerg Trauma Original Article OBJECTIVE: To design and conduct the effectiveness of Ketamine vs Dexmedetomidine in children’s sedation at emergency department (ED). METHODS: This randomized clinical trial study was carried out at the two trauma centers in Mashhad, Iran. The patients were divided into two groups by means of a random numbers table to be treated with Ketamine (N=20) or Dexmedetomidine (N=20). Their demographic information and sedation times of drugs were collected and analyzed. RESULTS: In general, sedation time was significantly higher in the ketamine group, 14.35 minutes (IQR:9.82-19) than in the dexmedetomidine group, 9.7 minutes (8.35-14.23) (p=0.023). Time of injection to complete anesthesia was 45.25 (IQR:30-58) and 72 (IQR:60.25-82) minutes in ketamine and dexmedetomidine groups, respectively (p<0.01). In the case of recovery, grade 4 of the Ramsey scale was statistically more prevalent in dexmedetomidine (45%) than in the ketamine group (p=0.0001). CONCLUSION: This study demonstrated that dexmedetomidine could be used in cases where a shorter sedation time is vital. Ketamine could be a better choice where full recovery time (from injection) matters most. Clinical Trial registration code: IR.MUMS.fm.REC.1396.534. Shiraz University of Medical Sciences 2023 /pmc/articles/PMC9923034/ /pubmed/36818052 http://dx.doi.org/10.30476/beat.2022.95647.1366 Text en © 2023 Trauma Research Center, Shiraz University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/All articles published by Bulletin of Emergency And Trauma are fully open access: immediately freely available to read, download and share. Bulletin of Emergency And Trauma articles are published under a Creative Commons license (CC-BY-NC).(https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Article Rezvani Kakhki, Behrang Fugerdi, Melika Abbasishaye, Zahra Feyz Dysfani, Hamideh Vafadar Moradi, Elnaz Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title | Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title_full | Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title_fullStr | Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title_full_unstemmed | Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title_short | Dexmedetomidine vs Ketamine for Pediatric Procedural Sedation in the Emergency Department: A Randomized Clinical Trial |
title_sort | dexmedetomidine vs ketamine for pediatric procedural sedation in the emergency department: a randomized clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923034/ https://www.ncbi.nlm.nih.gov/pubmed/36818052 http://dx.doi.org/10.30476/beat.2022.95647.1366 |
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