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Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders

Sleep and stress have complex interactions that are implicated in both physical diseases and psychiatric disorders. These interactions can be modulated by learning and memory, and involve additional interactions with the neuroimmune system. In this paper, we propose that stressful challenges induce...

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Autores principales: Sanford, Larry D., Wellman, Laurie L., Adkins, Austin M., Guo, Ming-Lei, Zhang, Ye, Ren, Rong, Yang, Linghui, Tang, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923229/
https://www.ncbi.nlm.nih.gov/pubmed/36793998
http://dx.doi.org/10.1016/j.ynstr.2023.100517
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author Sanford, Larry D.
Wellman, Laurie L.
Adkins, Austin M.
Guo, Ming-Lei
Zhang, Ye
Ren, Rong
Yang, Linghui
Tang, Xiangdong
author_facet Sanford, Larry D.
Wellman, Laurie L.
Adkins, Austin M.
Guo, Ming-Lei
Zhang, Ye
Ren, Rong
Yang, Linghui
Tang, Xiangdong
author_sort Sanford, Larry D.
collection PubMed
description Sleep and stress have complex interactions that are implicated in both physical diseases and psychiatric disorders. These interactions can be modulated by learning and memory, and involve additional interactions with the neuroimmune system. In this paper, we propose that stressful challenges induce integrated responses across multiple systems that can vary depending on situational variables in which the initial stress was experienced, and with the ability of the individual to cope with stress- and fear-inducing challenges. Differences in coping may involve differences in resilience and vulnerability and/or whether the stressful context allows adaptive learning and responses. We provide data demonstrating both common (corticosterone, SIH and fear behaviors) and distinguishing (sleep and neuroimmune) responses that are associated with an individual's ability to respond and relative resilience and vulnerability. We discuss neurocircuitry regulating integrated stress, sleep, neuroimmune and fear responses, and show that responses can be modulated at the neural level. Finally, we discuss factors that need to be considered in models of integrated stress responses and their relevance for understanding stress-related disorders in humans.
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spelling pubmed-99232292023-02-14 Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders Sanford, Larry D. Wellman, Laurie L. Adkins, Austin M. Guo, Ming-Lei Zhang, Ye Ren, Rong Yang, Linghui Tang, Xiangdong Neurobiol Stress Original Research Article Sleep and stress have complex interactions that are implicated in both physical diseases and psychiatric disorders. These interactions can be modulated by learning and memory, and involve additional interactions with the neuroimmune system. In this paper, we propose that stressful challenges induce integrated responses across multiple systems that can vary depending on situational variables in which the initial stress was experienced, and with the ability of the individual to cope with stress- and fear-inducing challenges. Differences in coping may involve differences in resilience and vulnerability and/or whether the stressful context allows adaptive learning and responses. We provide data demonstrating both common (corticosterone, SIH and fear behaviors) and distinguishing (sleep and neuroimmune) responses that are associated with an individual's ability to respond and relative resilience and vulnerability. We discuss neurocircuitry regulating integrated stress, sleep, neuroimmune and fear responses, and show that responses can be modulated at the neural level. Finally, we discuss factors that need to be considered in models of integrated stress responses and their relevance for understanding stress-related disorders in humans. Elsevier 2023-01-23 /pmc/articles/PMC9923229/ /pubmed/36793998 http://dx.doi.org/10.1016/j.ynstr.2023.100517 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Sanford, Larry D.
Wellman, Laurie L.
Adkins, Austin M.
Guo, Ming-Lei
Zhang, Ye
Ren, Rong
Yang, Linghui
Tang, Xiangdong
Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title_full Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title_fullStr Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title_full_unstemmed Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title_short Modeling integrated stress, sleep, fear and neuroimmune responses: Relevance for understanding trauma and stress-related disorders
title_sort modeling integrated stress, sleep, fear and neuroimmune responses: relevance for understanding trauma and stress-related disorders
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923229/
https://www.ncbi.nlm.nih.gov/pubmed/36793998
http://dx.doi.org/10.1016/j.ynstr.2023.100517
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