IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM

INTRODUCTION: The immunosuppressive tumor microenvironment (TME) is a major barrier to the efficacy of chimeric antigen receptor T cells (CAR-T cells) in glioblastoma (GBM). Transgenic expression of IL15 is one attractive strategy to modulate the TME. However, at present, it is unclear if IL15 could...

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Detalles Bibliográficos
Autores principales: Zannikou, Markella, Duffy, Joseph T, Levine, Rebecca N, Seblani, Maggie, Liu, Qianli, Presser, Aaron, Arrieta, Victor A, Chen, Christopher J, Sonabend, Adam M, Horbinski, Craig M, Lee-Chang, Catalina, Miska, Jason, Lesniak, Maciej S, Gottschalk, Stephen, Balyasnikova, Irina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923337/
https://www.ncbi.nlm.nih.gov/pubmed/36759014
http://dx.doi.org/10.1136/jitc-2022-006239

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