Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery

[Image: see text] The carbazole CBL0137 (1) is a lead for drug development against human African trypanosomiasis (HAT), a disease caused by Trypanosoma brucei. To advance 1 as a candidate drug, we synthesized new analogs that were evaluated for the physicochemical properties, antitrypanosome potency...

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Detalles Bibliográficos
Autores principales: Singh, Baljinder, Sharma, Amrita, Gunaganti, Naresh, Rivers, Mitch, Gadekar, Pradip K., Greene, Brady, Chichioco, Michael, Sanz-Rodriguez, Carlos E., Fu, Courtney, LeBlanc, Catherine, Burchfield, Erin, Sharif, Nyle, Hoffman, Benjamin, Kumar, Gaurav, Purmal, Andrei, Mensa-Wilmot, Kojo, Pollastri, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923759/
https://www.ncbi.nlm.nih.gov/pubmed/36695630
http://dx.doi.org/10.1021/acs.jmedchem.2c01767

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