Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation

The prenylation of proteins is involved in a variety of biological functions. However, it remains unknown whether it plays an important role in the morphogenesis of the cerebellum. To address this question, we generated a mouse model, in which the geranylgeranyl pyrophosphate synthase (Ggps1) gene i...

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Detalles Bibliográficos
Autores principales: Cheng, Qi, Wu, Jing, Xia, Yingqian, Cheng, Qing, Zhao, Yinjuan, Zhu, Peixiang, Zhang, Wangling, Zhang, Shihu, Zhang, Lei, Yuan, Yushan, Li, Chaojun, Chen, Guiquan, Xue, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923931/
https://www.ncbi.nlm.nih.gov/pubmed/36782228
http://dx.doi.org/10.1186/s13041-023-01010-4

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