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Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, and immunotherapy remain the main treatments for CRC, but improvement in the over...

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Autores principales: Chen, Jin-Fang, Wu, Shi-Wei, Shi, Zi-Man, Hu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923939/
https://www.ncbi.nlm.nih.gov/pubmed/36782251
http://dx.doi.org/10.1186/s13020-023-00719-7
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author Chen, Jin-Fang
Wu, Shi-Wei
Shi, Zi-Man
Hu, Bing
author_facet Chen, Jin-Fang
Wu, Shi-Wei
Shi, Zi-Man
Hu, Bing
author_sort Chen, Jin-Fang
collection PubMed
description Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, and immunotherapy remain the main treatments for CRC, but improvement in the overall survival rate and quality of life is urgently needed. Traditional Chinese medicine (TCM) has a long history of preventing and treating CRC. It could affect CRC cell proliferation, apoptosis, cell cycle, migration, invasion, autophagy, epithelial–mesenchymal transition, angiogenesis, and chemoresistance by regulating multiple signaling pathways, such as PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, epidermal growth factor receptors, p53, TGF-β, mTOR, Hedgehog, and immunomodulatory signaling pathways. In this paper, the main signaling pathways and potential targets of TCM and its active ingredients in the treatment of CRC were systematically summarized, providing a theoretical basis for treating CRC with TCM and new ideas for further exploring the pathogenesis of CRC and developing new anti-CRC drugs.
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spelling pubmed-99239392023-02-14 Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action Chen, Jin-Fang Wu, Shi-Wei Shi, Zi-Man Hu, Bing Chin Med Review Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, and immunotherapy remain the main treatments for CRC, but improvement in the overall survival rate and quality of life is urgently needed. Traditional Chinese medicine (TCM) has a long history of preventing and treating CRC. It could affect CRC cell proliferation, apoptosis, cell cycle, migration, invasion, autophagy, epithelial–mesenchymal transition, angiogenesis, and chemoresistance by regulating multiple signaling pathways, such as PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, epidermal growth factor receptors, p53, TGF-β, mTOR, Hedgehog, and immunomodulatory signaling pathways. In this paper, the main signaling pathways and potential targets of TCM and its active ingredients in the treatment of CRC were systematically summarized, providing a theoretical basis for treating CRC with TCM and new ideas for further exploring the pathogenesis of CRC and developing new anti-CRC drugs. BioMed Central 2023-02-13 /pmc/articles/PMC9923939/ /pubmed/36782251 http://dx.doi.org/10.1186/s13020-023-00719-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Jin-Fang
Wu, Shi-Wei
Shi, Zi-Man
Hu, Bing
Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title_full Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title_fullStr Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title_full_unstemmed Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title_short Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
title_sort traditional chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9923939/
https://www.ncbi.nlm.nih.gov/pubmed/36782251
http://dx.doi.org/10.1186/s13020-023-00719-7
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