An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

Broadly neutralizing antibodies are an important treatment for individuals with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody-based therapeutics are also essential for pandemic preparedness against future Sarbecovirus outbreaks....

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Autores principales: Schepens, Bert, van Schie, Loes, Nerinckx, Wim, Roose, Kenny, Van Breedam, Wander, Fijalkowska, Daria, Devos, Simon, Weyts, Wannes, De Cae, Sieglinde, Vanmarcke, Sandrine, Lonigro, Chiara, Eeckhaut, Hannah, Van Herpe, Dries, Borloo, Jimmy, Oliveira, Ana Filipa, Catani, João Paulo Portela, Creytens, Sarah, De Vlieger, Dorien, Michielsen, Gitte, Marchan, Jackeline Cecilia Zavala, Moschonas, George D., Rossey, Iebe, Sedeyn, Koen, Van Hecke, Annelies, Zhang, Xin, Langendries, Lana, Jacobs, Sofie, ter Horst, Sebastiaan, Seldeslachts, Laura, Liesenborghs, Laurens, Boudewijns, Robbert, Thibaut, Hendrik Jan, Dallmeier, Kai, Velde, Greetje Vande, Weynand, Birgit, Beer, Julius, Schnepf, Daniel, Ohnemus, Annette, Remory, Isabel, Foo, Caroline S., Abdelnabi, Rana, Maes, Piet, Kaptein, Suzanne J. F., Rocha-Pereira, Joana, Jochmans, Dirk, Delang, Leen, Peelman, Frank, Staeheli, Peter, Schwemmle, Martin, Devoogdt, Nick, Tersago, Dominique, Germani, Massimiliano, Heads, James, Henry, Alistair, Popplewell, Andrew, Ellis, Mark, Brady, Kevin, Turner, Alison, Dombrecht, Bruno, Stortelers, Catelijne, Neyts, Johan, Callewaert, Nico, Saelens, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924070/
https://www.ncbi.nlm.nih.gov/pubmed/34609205
http://dx.doi.org/10.1126/scitranslmed.abi7826

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