MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de novo enhancers. Ewing sarcoma thus provides a...

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Detalles Bibliográficos
Autores principales: Vital, Tamara, Wali, Aminah, Butler, Kyle V., Xiong, Yan, Foster, Joseph P., Marcel, Shelsa S., McFadden, Andrew W., Nguyen, Valerie U., Bailey, Benton M., Lamb, Kelsey N., James, Lindsey I., Frye, Stephen V., Mosely, Amber L., Jin, Jian, Pattenden, Samantha G., Davis, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924231/
https://www.ncbi.nlm.nih.gov/pubmed/36793594
http://dx.doi.org/10.3389/fonc.2023.1099550

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