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Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer
OBJECTIVE: To evaluate predictive factors between serum inflammatory markers and malignancy potential of endometrium. METHODS: This retrospective study was conducted at the gynecological oncology unit, department of obstetrics and gynecology, at the faculty of medicine of Thammasat University. The s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924334/ https://www.ncbi.nlm.nih.gov/pubmed/36308354 http://dx.doi.org/10.31557/APJCP.2022.23.10.3317 |
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author | Muangto, Teerapat Mairaing, Karicha Poomtavorn, Yenrudee Thaweekul, Yuthadej Punyashthira, Awassada Chantawong, Nopwaree Wisarnsirirak, Pattra Pattaraarchachai, Junya Suwannarurk, Komsun |
author_facet | Muangto, Teerapat Mairaing, Karicha Poomtavorn, Yenrudee Thaweekul, Yuthadej Punyashthira, Awassada Chantawong, Nopwaree Wisarnsirirak, Pattra Pattaraarchachai, Junya Suwannarurk, Komsun |
author_sort | Muangto, Teerapat |
collection | PubMed |
description | OBJECTIVE: To evaluate predictive factors between serum inflammatory markers and malignancy potential of endometrium. METHODS: This retrospective study was conducted at the gynecological oncology unit, department of obstetrics and gynecology, at the faculty of medicine of Thammasat University. The study period was from 2017 to 2020. Endometrial cancer and benign gynecologic disease cases who underwent hysterectomy (with or without adnexectomy) during the study period were recruited. Demographic characteristics, histopathology reports and serum markers were also collected. RESULTS: The study included a study group of 49 participants with endometrial cancer and a control group consisting of 119 cases of benign uterine disease. The study group had statistically significantly higher mean ages, proportional menopausal status and instances of underlying diseases when compared with the control group. Neutrophil/Lymphocyte ratios (NLR) and Platelet/Lymphocyte ratios (PLR) could not meaningfully predict the malignant potential of endometrium in hysterectomy specimens. NLR and PLR were statistically associated with depth of myometrial invasion (MI) in endometrial cancer cases. NLR equal to or greater than 1.93 predicted MI more than half thickness with sensitivity, specificity, accuracy, positive (PPV) and negative predictive value (NPV) at a percentage of 83.3, 52.8, 37.0, 90.5 and 60.4, respectively. PLR equal to or greater than 134.95 predicted MI of greater than fifty percent thickness with sensitivity, specificity, accuracy, PPV and NPV at 75.0, 55.6, 36.0, 87.0 and 60.4 percent, respectively. CONCLUSION: NLR and PLR have positive associations with myometrial invasion of endometrial cancer. |
format | Online Article Text |
id | pubmed-9924334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-99243342023-02-16 Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer Muangto, Teerapat Mairaing, Karicha Poomtavorn, Yenrudee Thaweekul, Yuthadej Punyashthira, Awassada Chantawong, Nopwaree Wisarnsirirak, Pattra Pattaraarchachai, Junya Suwannarurk, Komsun Asian Pac J Cancer Prev Research Article OBJECTIVE: To evaluate predictive factors between serum inflammatory markers and malignancy potential of endometrium. METHODS: This retrospective study was conducted at the gynecological oncology unit, department of obstetrics and gynecology, at the faculty of medicine of Thammasat University. The study period was from 2017 to 2020. Endometrial cancer and benign gynecologic disease cases who underwent hysterectomy (with or without adnexectomy) during the study period were recruited. Demographic characteristics, histopathology reports and serum markers were also collected. RESULTS: The study included a study group of 49 participants with endometrial cancer and a control group consisting of 119 cases of benign uterine disease. The study group had statistically significantly higher mean ages, proportional menopausal status and instances of underlying diseases when compared with the control group. Neutrophil/Lymphocyte ratios (NLR) and Platelet/Lymphocyte ratios (PLR) could not meaningfully predict the malignant potential of endometrium in hysterectomy specimens. NLR and PLR were statistically associated with depth of myometrial invasion (MI) in endometrial cancer cases. NLR equal to or greater than 1.93 predicted MI more than half thickness with sensitivity, specificity, accuracy, positive (PPV) and negative predictive value (NPV) at a percentage of 83.3, 52.8, 37.0, 90.5 and 60.4, respectively. PLR equal to or greater than 134.95 predicted MI of greater than fifty percent thickness with sensitivity, specificity, accuracy, PPV and NPV at 75.0, 55.6, 36.0, 87.0 and 60.4 percent, respectively. CONCLUSION: NLR and PLR have positive associations with myometrial invasion of endometrial cancer. West Asia Organization for Cancer Prevention 2022-10 /pmc/articles/PMC9924334/ /pubmed/36308354 http://dx.doi.org/10.31557/APJCP.2022.23.10.3317 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. https://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Research Article Muangto, Teerapat Mairaing, Karicha Poomtavorn, Yenrudee Thaweekul, Yuthadej Punyashthira, Awassada Chantawong, Nopwaree Wisarnsirirak, Pattra Pattaraarchachai, Junya Suwannarurk, Komsun Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title | Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title_full | Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title_fullStr | Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title_full_unstemmed | Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title_short | Study on Preoperative Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratio (PLR) as a Predictive Factor in Endometrial Cancer |
title_sort | study on preoperative neutrophil/lymphocyte (nlr) and platelet/lymphocyte ratio (plr) as a predictive factor in endometrial cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924334/ https://www.ncbi.nlm.nih.gov/pubmed/36308354 http://dx.doi.org/10.31557/APJCP.2022.23.10.3317 |
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