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Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study
BACKGROUND: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile. HYPOTHESIS: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI). METHODS: D...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Greater Baltimore Medical Center
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924641/ https://www.ncbi.nlm.nih.gov/pubmed/36816160 http://dx.doi.org/10.55729/2000-9666.1123 |
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author | Chatterjee, Tulika Bansal, Saurabh Abuzar, Asif Hussain, Habiba Gupta, Latika |
author_facet | Chatterjee, Tulika Bansal, Saurabh Abuzar, Asif Hussain, Habiba Gupta, Latika |
author_sort | Chatterjee, Tulika |
collection | PubMed |
description | BACKGROUND: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile. HYPOTHESIS: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI). METHODS: Data was collected by retrospective chart query. Severe CDI was defined as a white blood cell count of more than 15,000 (x 109 cells/L) or serum creatinine levels greater than 1.5 mg/dL. To examine the association between the primary outcome (severe CDI) and BMI, the factors of age, gender, albumin level, ICU admission, antibiotic use within 3 months of admission, diabetes, and hypertension were also considered. Patients with chronic kidney disease, end-stage liver disease, pregnancy, inflammatory bowel disease, previous gastrointestinal surgeries, active malignancy, and immunosuppressed were excluded. RESULTS: 219 patients were included in the final study. Of these 52.8% of patients had severe CDI, and 47.2% had non-severe CDI. Compared to normal-weight patients, risk of severe CDI was not influenced by being obese (OR = 1.26, p = 0.5119), overweight (OR = 1.65, p = 0.21), or underweight (OR = 1.05, p = 0.9383). Males had higher odds of having severe CDI when compared with females (OR = 1.76, 95% CI = 1.03 to 3.01, p = 0.0395). Albumin levels greater than 3.0 mg/dL were associated with lower odds of having severe CDI (OR = 0.41, 95% CI = 0.27 to 0.62, p< 0.0001). CONCLUSION: BMI of an individual does not appear to be associated with the severity of CDI. |
format | Online Article Text |
id | pubmed-9924641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Greater Baltimore Medical Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-99246412023-02-16 Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study Chatterjee, Tulika Bansal, Saurabh Abuzar, Asif Hussain, Habiba Gupta, Latika J Community Hosp Intern Med Perspect Research Article BACKGROUND: Obesity is associated with a relative increase in bacterial phyla like firmicutes, which helps in the colonization of Clostridioides Difficile. HYPOTHESIS: Individuals with increased BMI (greater than 25) are more susceptible to severe Clostridioides Difficile infection (CDI). METHODS: Data was collected by retrospective chart query. Severe CDI was defined as a white blood cell count of more than 15,000 (x 109 cells/L) or serum creatinine levels greater than 1.5 mg/dL. To examine the association between the primary outcome (severe CDI) and BMI, the factors of age, gender, albumin level, ICU admission, antibiotic use within 3 months of admission, diabetes, and hypertension were also considered. Patients with chronic kidney disease, end-stage liver disease, pregnancy, inflammatory bowel disease, previous gastrointestinal surgeries, active malignancy, and immunosuppressed were excluded. RESULTS: 219 patients were included in the final study. Of these 52.8% of patients had severe CDI, and 47.2% had non-severe CDI. Compared to normal-weight patients, risk of severe CDI was not influenced by being obese (OR = 1.26, p = 0.5119), overweight (OR = 1.65, p = 0.21), or underweight (OR = 1.05, p = 0.9383). Males had higher odds of having severe CDI when compared with females (OR = 1.76, 95% CI = 1.03 to 3.01, p = 0.0395). Albumin levels greater than 3.0 mg/dL were associated with lower odds of having severe CDI (OR = 0.41, 95% CI = 0.27 to 0.62, p< 0.0001). CONCLUSION: BMI of an individual does not appear to be associated with the severity of CDI. Greater Baltimore Medical Center 2022-11-07 /pmc/articles/PMC9924641/ /pubmed/36816160 http://dx.doi.org/10.55729/2000-9666.1123 Text en © 2022 Greater Baltimore Medical Center https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ). |
spellingShingle | Research Article Chatterjee, Tulika Bansal, Saurabh Abuzar, Asif Hussain, Habiba Gupta, Latika Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title | Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title_full | Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title_fullStr | Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title_full_unstemmed | Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title_short | Is Increased BMI a Risk Factor for Developing Severe Clostridioides Difficile Infection? A Retrospective Study |
title_sort | is increased bmi a risk factor for developing severe clostridioides difficile infection? a retrospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924641/ https://www.ncbi.nlm.nih.gov/pubmed/36816160 http://dx.doi.org/10.55729/2000-9666.1123 |
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