Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Combining optimized spike (S) protein-encoding mRNA vaccines to target multiple SARS-CoV-2 variants could improve control of the COVID-19 pandemic. We compare monovalent and bivalent mRNA vaccines encoding B.1.351 (Beta) and/or B.1.617.2 (Delta) SARS-CoV-2 S-protein in a transgenic mouse and a Wista...

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Detalles Bibliográficos
Autores principales: Corleis, Björn, Hoffmann, Donata, Rauch, Susanne, Fricke, Charlie, Roth, Nicole, Gergen, Janina, Kovacikova, Kristina, Schlottau, Kore, Halwe, Nico Joel, Ulrich, Lorenz, Schön, Jacob, Wernike, Kerstin, Widera, Marek, Ciesek, Sandra, Mueller, Stefan O., Mettenleiter, Thomas C., Maione, Domenico, Petsch, Benjamin, Beer, Martin, Dorhoi, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924835/
https://www.ncbi.nlm.nih.gov/pubmed/36781853
http://dx.doi.org/10.1038/s41467-023-36110-1

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