SATB2, coordinated with CUX1, regulates IL‐1β‐induced senescence‐like phenotype in endothelial cells by fine‐tuning the atherosclerosis‐associated p16(INK4a) expression

Genome‐wide association studies (GWAS) have validated a strong association of atherosclerosis with the CDKN2A/B locus, a locus harboring three tumor suppressor genes: p14 ( ARF ), p15 ( INK4b ), and p16 ( INK4a ). Post‐GWAS functional analysis reveals that CUX is a transcriptional activator of p16(I...

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Detalles Bibliográficos
Autores principales: Wu, Ting, Wu, Yuwei, Jiang, Danli, Sun, Wei, Zou, Meijuan, Vasamsetti, Sathish Babu, Dutta, Partha, Leers, Steven A., Di, Wu, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924951/
https://www.ncbi.nlm.nih.gov/pubmed/36633253
http://dx.doi.org/10.1111/acel.13765

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