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Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss
The cause of sudden sensorineural hearing loss (SSNHL) is uncertain in a significant number of patients. A vascular etiology has been proposed because SSNHL increases the risk of developing a stroke. Cardiovascular risk factors can cause cerebral small vessel disease (CSVD). The presence of CSVD in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924965/ https://www.ncbi.nlm.nih.gov/pubmed/36727811 http://dx.doi.org/10.1097/MAO.0000000000003813 |
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author | Oussoren, Fieke K. van Leeuwen, Roeland B. Schermer, Tjard R. Poulsen, Louise N. F. Kardux, Joost J. Bruintjes, Tjasse D. |
author_facet | Oussoren, Fieke K. van Leeuwen, Roeland B. Schermer, Tjard R. Poulsen, Louise N. F. Kardux, Joost J. Bruintjes, Tjasse D. |
author_sort | Oussoren, Fieke K. |
collection | PubMed |
description | The cause of sudden sensorineural hearing loss (SSNHL) is uncertain in a significant number of patients. A vascular etiology has been proposed because SSNHL increases the risk of developing a stroke. Cardiovascular risk factors can cause cerebral small vessel disease (CSVD). The presence of CSVD in turn raises the risk of stroke. AIM: The aim of this study was to compare the presence of CSVD and cardiovascular risk factors in elderly patients with idiopathic SSNHL (iSSNHL) to a control cohort. METHOD: Patients with iSSNHL of 50 years and older were compared with a control cohort with patients suspected of trigeminal neuralgia or vestibular paroxysmia. The primary outcome was the difference in the number of white matter hyperintensities using the ordinal Fazekas scale. Secondary outcomes were the presence of brain infarctions on MRI and the difference in cardiovascular risk factors. RESULTS: In the SSNHL cohort, Fazekas score 2 was most frequently seen compared with Fazekas 1 in the control cohort. The distribution of Fazekas scores did not differ significantly. The sum of the Fazekas scores were 13,925 and 14,042 for iSSNHL and controls, respectively (p = 0.908). Brain infarctions were seen in 8 patients with iSSNHL (n = 118) and in 13 patients in the control cohort (n = 118) (p = 0.361). None of the cardiovascular risk factors were more frequently seen in the iSSNHL cohort. CONCLUSION: Patients with iSSNHL did not exhibit more CSVD on MRI than controls. This result is in contrast with previous literature demonstrating a higher risk of stroke in patients with iSSNHL than in controls. A prospective analysis with a larger study population is therefore warranted. |
format | Online Article Text |
id | pubmed-9924965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-99249652023-02-14 Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss Oussoren, Fieke K. van Leeuwen, Roeland B. Schermer, Tjard R. Poulsen, Louise N. F. Kardux, Joost J. Bruintjes, Tjasse D. Otol Neurotol Middle Ear and Mastoid Disease The cause of sudden sensorineural hearing loss (SSNHL) is uncertain in a significant number of patients. A vascular etiology has been proposed because SSNHL increases the risk of developing a stroke. Cardiovascular risk factors can cause cerebral small vessel disease (CSVD). The presence of CSVD in turn raises the risk of stroke. AIM: The aim of this study was to compare the presence of CSVD and cardiovascular risk factors in elderly patients with idiopathic SSNHL (iSSNHL) to a control cohort. METHOD: Patients with iSSNHL of 50 years and older were compared with a control cohort with patients suspected of trigeminal neuralgia or vestibular paroxysmia. The primary outcome was the difference in the number of white matter hyperintensities using the ordinal Fazekas scale. Secondary outcomes were the presence of brain infarctions on MRI and the difference in cardiovascular risk factors. RESULTS: In the SSNHL cohort, Fazekas score 2 was most frequently seen compared with Fazekas 1 in the control cohort. The distribution of Fazekas scores did not differ significantly. The sum of the Fazekas scores were 13,925 and 14,042 for iSSNHL and controls, respectively (p = 0.908). Brain infarctions were seen in 8 patients with iSSNHL (n = 118) and in 13 patients in the control cohort (n = 118) (p = 0.361). None of the cardiovascular risk factors were more frequently seen in the iSSNHL cohort. CONCLUSION: Patients with iSSNHL did not exhibit more CSVD on MRI than controls. This result is in contrast with previous literature demonstrating a higher risk of stroke in patients with iSSNHL than in controls. A prospective analysis with a larger study population is therefore warranted. Lippincott Williams & Wilkins 2023-03 2023-01-21 /pmc/articles/PMC9924965/ /pubmed/36727811 http://dx.doi.org/10.1097/MAO.0000000000003813 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Otology & Neurotology, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Middle Ear and Mastoid Disease Oussoren, Fieke K. van Leeuwen, Roeland B. Schermer, Tjard R. Poulsen, Louise N. F. Kardux, Joost J. Bruintjes, Tjasse D. Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title | Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title_full | Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title_fullStr | Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title_full_unstemmed | Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title_short | Cerebral Small Vessel Disease in Elderly Patients with Sudden Sensorineural Hearing Loss |
title_sort | cerebral small vessel disease in elderly patients with sudden sensorineural hearing loss |
topic | Middle Ear and Mastoid Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924965/ https://www.ncbi.nlm.nih.gov/pubmed/36727811 http://dx.doi.org/10.1097/MAO.0000000000003813 |
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