Cargando…
Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease manifested as painful inflamed lesions including deep-seated nodules, abscesses and sinus tracts. The exact aetiology of HS is unclear. Recent evidence suggests that immune dysregulation plays a crucial role in pathogenes...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924995/ https://www.ncbi.nlm.nih.gov/pubmed/36780439 http://dx.doi.org/10.1371/journal.pone.0281688 |
_version_ | 1784887970933768192 |
---|---|
author | Petrasca, Andreea Hambly, Roisin Molloy, Oonagh Kearns, Sean Moran, Barry Smith, Conor M. Hughes, Rosalind O’Donnell, Margaret Zaborowski, Alexandra Winter, Desmond Fletcher, Jean M. Kirby, Brian Malara, Anna |
author_facet | Petrasca, Andreea Hambly, Roisin Molloy, Oonagh Kearns, Sean Moran, Barry Smith, Conor M. Hughes, Rosalind O’Donnell, Margaret Zaborowski, Alexandra Winter, Desmond Fletcher, Jean M. Kirby, Brian Malara, Anna |
author_sort | Petrasca, Andreea |
collection | PubMed |
description | Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease manifested as painful inflamed lesions including deep-seated nodules, abscesses and sinus tracts. The exact aetiology of HS is unclear. Recent evidence suggests that immune dysregulation plays a crucial role in pathogenesis and disease progression. Innate lymphoid cells (ILC) are a recently identified immune cell subset involved in mediating immunity, however their role in HS has not yet been investigated. Three distinct subsets of ILC- ILC1, ILC2 and ILC3 have been described, and these are involved in skin tissue homeostasis and pathologic inflammation associated with autoimmunity and allergic diseases. In this study, we analysed by multiparameter flow cytometry the frequencies of ILC subsets in skin and peripheral blood mononuclear cells (PBMC) of HS patients and compared these to healthy control subjects and psoriasis patients. The absolute numbers of total ILC and subsets thereof were significantly reduced in the blood of HS patients relative to healthy controls. However, when patients were stratified according to treatment, this reduction was no longer observed in patients undergoing anti-TNF treatment. In HS lesional skin the absolute numbers of ILC were significantly increased relative to control skin. Furthermore, the frequencies of total ILC as well as ILC2 and ILC3 were significantly higher in non-lesional than lesional HS skin. This study analysed for the first time the presence of ILC subsets in the blood and skin of HS patients. Our findings suggest that ILC may participate in HS pathogenesis. |
format | Online Article Text |
id | pubmed-9924995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99249952023-02-14 Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa Petrasca, Andreea Hambly, Roisin Molloy, Oonagh Kearns, Sean Moran, Barry Smith, Conor M. Hughes, Rosalind O’Donnell, Margaret Zaborowski, Alexandra Winter, Desmond Fletcher, Jean M. Kirby, Brian Malara, Anna PLoS One Research Article Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease manifested as painful inflamed lesions including deep-seated nodules, abscesses and sinus tracts. The exact aetiology of HS is unclear. Recent evidence suggests that immune dysregulation plays a crucial role in pathogenesis and disease progression. Innate lymphoid cells (ILC) are a recently identified immune cell subset involved in mediating immunity, however their role in HS has not yet been investigated. Three distinct subsets of ILC- ILC1, ILC2 and ILC3 have been described, and these are involved in skin tissue homeostasis and pathologic inflammation associated with autoimmunity and allergic diseases. In this study, we analysed by multiparameter flow cytometry the frequencies of ILC subsets in skin and peripheral blood mononuclear cells (PBMC) of HS patients and compared these to healthy control subjects and psoriasis patients. The absolute numbers of total ILC and subsets thereof were significantly reduced in the blood of HS patients relative to healthy controls. However, when patients were stratified according to treatment, this reduction was no longer observed in patients undergoing anti-TNF treatment. In HS lesional skin the absolute numbers of ILC were significantly increased relative to control skin. Furthermore, the frequencies of total ILC as well as ILC2 and ILC3 were significantly higher in non-lesional than lesional HS skin. This study analysed for the first time the presence of ILC subsets in the blood and skin of HS patients. Our findings suggest that ILC may participate in HS pathogenesis. Public Library of Science 2023-02-13 /pmc/articles/PMC9924995/ /pubmed/36780439 http://dx.doi.org/10.1371/journal.pone.0281688 Text en © 2023 Petrasca et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Petrasca, Andreea Hambly, Roisin Molloy, Oonagh Kearns, Sean Moran, Barry Smith, Conor M. Hughes, Rosalind O’Donnell, Margaret Zaborowski, Alexandra Winter, Desmond Fletcher, Jean M. Kirby, Brian Malara, Anna Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title | Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title_full | Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title_fullStr | Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title_full_unstemmed | Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title_short | Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa |
title_sort | innate lymphoid cell (ilc) subsets are enriched in the skin of patients with hidradenitis suppurativa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924995/ https://www.ncbi.nlm.nih.gov/pubmed/36780439 http://dx.doi.org/10.1371/journal.pone.0281688 |
work_keys_str_mv | AT petrascaandreea innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT hamblyroisin innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT molloyoonagh innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT kearnssean innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT moranbarry innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT smithconorm innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT hughesrosalind innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT odonnellmargaret innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT zaborowskialexandra innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT winterdesmond innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT fletcherjeanm innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT kirbybrian innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa AT malaraanna innatelymphoidcellilcsubsetsareenrichedintheskinofpatientswithhidradenitissuppurativa |