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Comparison of the efficacy of second and third generation lentiviral vector transduced CAR CD19 T cells for use in the treatment of acute lymphoblastic leukemia both in vitro and in vivo models

T cells genetically engineered to express a chimeric antigen receptor (CAR) specifically binding to a CD19 antigen has become the frontline of hematological malignancies immunotherapy. Their remarkable antitumor effect has exerted complete remission in treating B-cell malignancies. Although successf...

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Detalles Bibliográficos
Autores principales:	Sawaisorn, Piamsiri, Atjanasuppat, Korakot, Uaesoontrachoon, Kitipong, Rattananon, Parin, Treesuppharat, Worapapar, Hongeng, Suradej, Anurathapan, Usanarat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925013/ https://www.ncbi.nlm.nih.gov/pubmed/36780428 http://dx.doi.org/10.1371/journal.pone.0281735

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