NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

Chronic stress can produce reward system deficits (i.e., anhedonia) and other common symptoms associated with depressive disorders, as well as neural circuit hypofunction in the medial prefrontal cortex (mPFC). However, the molecular mechanisms by which chronic stress promotes depressive-like behavi...

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Detalles Bibliográficos
Autores principales: Hughes, Brandon W, Siemsen, Benjamin M, Tsvetkov, Evgeny, Berto, Stefano, Kumar, Jaswinder, Cornbrooks, Rebecca G, Akiki, Rose Marie, Cho, Jennifer Y, Carter, Jordan S, Snyder, Kirsten K, Assali, Ahlem, Scofield, Michael D, Cowan, Christopher W, Taniguchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925055/
https://www.ncbi.nlm.nih.gov/pubmed/36780219
http://dx.doi.org/10.7554/eLife.75631

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