A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through interactions with phospholipids and transmembrane domains of proteins. However, as cholesterol concentration rises above the PM’s sequestration capacity, a new pool of cholesterol, called accessible choleste...

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Detalles Bibliográficos
Autores principales: Heisler, David B, Johnson, Kristen A, Ma, Duo H, Ohlson, Maikke B, Zhang, Lishu, Tran, Michelle, Corley, Chase D, Abrams, Michael E, McDonald, Jeffrey G, Schoggins, John W, Alto, Neal M, Radhakrishnan, Arun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925056/
https://www.ncbi.nlm.nih.gov/pubmed/36695568
http://dx.doi.org/10.7554/eLife.83534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925056/
https://www.ncbi.nlm.nih.gov/pubmed/36695568
http://dx.doi.org/10.7554/eLife.83534

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