Exercise-brain interaction of neuroplasticity: empirical evidence in the rodent adaptation

[PURPOSE]: Exercise is gradually being recognized as an essential component of brain plasticity at the molecular, functional, and structural changes levels. What are the causes of the observed exercise reimbursements in neuroscience? Several types of exercises have been studied in various doses in neurological, physiological, psychological, and biochemical experiments. More clarity is required to reveal exercise-brain interactions such as optimal exercise condition variables and neuroplasticity. [METHODS]: This review briefly highlights the empirical evidence of the positive effects neuroprotective activity on neuroscientific advancement. [RESULTS]: The key areas are as follows: (a) stress exercise model using rodents, (b) hippocampal activation and plasticity with exercise, (c) glycogen metabolism in the brain, and (d) adaptation as a high-intensity interval training model in animals involved in exercise-induced brain plasticity. [CONCLUSION]: Overall, exercise-induced molecular, functional, and structural changes in the neuronal system may affect rodents’ performance. This study emphasizes the significance of understanding exercise neuroscience and makes recommendations for future research.