Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes t...

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Detalles Bibliográficos
Autores principales: Chan, Gary KL, Maisel, Samantha, Hwang, Yeonjoo C, Pascual, Bryan C, Wolber, Rebecca RB, Vu, Phuong, Patra, Krushna C, Bouhaddou, Mehdi, Kenerson, Heidi L, Lim, Huat C, Long, Donald, Yeung, Raymond S, Sethupathy, Praveen, Swaney, Danielle L, Krogan, Nevan J, Turnham, Rigney E, Riehle, Kimberly J, Scott, John D, Bardeesy, Nabeel, Gordan, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925115/
https://www.ncbi.nlm.nih.gov/pubmed/36692000
http://dx.doi.org/10.7554/eLife.69521

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