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Exploring neurotransmitters and their receptors for breast cancer prevention and treatment
While psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions be...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925324/ https://www.ncbi.nlm.nih.gov/pubmed/36793869 http://dx.doi.org/10.7150/thno.81403 |
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author | Li, Ruo Qi Zhao, Xiao Hong Zhu, Qin Liu, Tao Hondermarck, Hubert Thorne, Rick F. Zhang, Xu Dong Gao, Jin Nan |
author_facet | Li, Ruo Qi Zhao, Xiao Hong Zhu, Qin Liu, Tao Hondermarck, Hubert Thorne, Rick F. Zhang, Xu Dong Gao, Jin Nan |
author_sort | Li, Ruo Qi |
collection | PubMed |
description | While psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions between neurotransmitters and their receptors expressed on breast cancer cells and other types of cells in the tumor microenvironment, which activate various intracellular signaling pathways. Importantly, the manipulation of these interactions is emerging as a potential avenue for breast cancer prevention and treatment. However, an important caveat is that the same neurotransmitter can exert multiple and sometimes opposing effects. In addition, certain neurotransmitters can be produced and secreted by non-neuronal cells including breast cancer cells that similarly activate intracellular signaling upon binding to their receptors. In this review we dissect the evidence for the emerging paradigm linking neurotransmitters and their receptors with breast cancer. Foremost, we explore the intricacies of such neurotransmitter-receptor interactions, including those that impinge on other cellular components of the tumor microenvironment, such as endothelial cells and immune cells. Moreover, we discuss findings where clinical agents used to treat neurological and/or psychological disorders have exhibited preventive/therapeutic effects against breast cancer in either associative or pre-clinical studies. Further, we elaborate on the current progress to identify druggable components of the psychological-neurological nexus that can be exploited for the prevention and treatment of breast cancer as well as other tumor types. We also provide our perspectives regarding future challenges in this field where multidisciplinary cooperation is a paramount requirement. |
format | Online Article Text |
id | pubmed-9925324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-99253242023-02-14 Exploring neurotransmitters and their receptors for breast cancer prevention and treatment Li, Ruo Qi Zhao, Xiao Hong Zhu, Qin Liu, Tao Hondermarck, Hubert Thorne, Rick F. Zhang, Xu Dong Gao, Jin Nan Theranostics Review While psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions between neurotransmitters and their receptors expressed on breast cancer cells and other types of cells in the tumor microenvironment, which activate various intracellular signaling pathways. Importantly, the manipulation of these interactions is emerging as a potential avenue for breast cancer prevention and treatment. However, an important caveat is that the same neurotransmitter can exert multiple and sometimes opposing effects. In addition, certain neurotransmitters can be produced and secreted by non-neuronal cells including breast cancer cells that similarly activate intracellular signaling upon binding to their receptors. In this review we dissect the evidence for the emerging paradigm linking neurotransmitters and their receptors with breast cancer. Foremost, we explore the intricacies of such neurotransmitter-receptor interactions, including those that impinge on other cellular components of the tumor microenvironment, such as endothelial cells and immune cells. Moreover, we discuss findings where clinical agents used to treat neurological and/or psychological disorders have exhibited preventive/therapeutic effects against breast cancer in either associative or pre-clinical studies. Further, we elaborate on the current progress to identify druggable components of the psychological-neurological nexus that can be exploited for the prevention and treatment of breast cancer as well as other tumor types. We also provide our perspectives regarding future challenges in this field where multidisciplinary cooperation is a paramount requirement. Ivyspring International Publisher 2023-01-31 /pmc/articles/PMC9925324/ /pubmed/36793869 http://dx.doi.org/10.7150/thno.81403 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Li, Ruo Qi Zhao, Xiao Hong Zhu, Qin Liu, Tao Hondermarck, Hubert Thorne, Rick F. Zhang, Xu Dong Gao, Jin Nan Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title | Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title_full | Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title_fullStr | Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title_full_unstemmed | Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title_short | Exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
title_sort | exploring neurotransmitters and their receptors for breast cancer prevention and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925324/ https://www.ncbi.nlm.nih.gov/pubmed/36793869 http://dx.doi.org/10.7150/thno.81403 |
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