APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

Double-stranded RNA produced during viral replication and transcription activates both protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression and replication through host shutoff of translation. In this study, we find that APOBEC3B forms a complex with PABPC1 to stim...

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Detalles Bibliográficos
Autores principales: Manjunath, Lavanya, Oh, Sunwoo, Ortega, Pedro, Bouin, Alexis, Bournique, Elodie, Sanchez, Ambrocio, Martensen, Pia Møller, Auerbach, Ashley A., Becker, Jordan T., Seldin, Marcus, Harris, Reuben S., Semler, Bert L., Buisson, Rémi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925369/
https://www.ncbi.nlm.nih.gov/pubmed/36781883
http://dx.doi.org/10.1038/s41467-023-36445-9

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