Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancest...

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Autores principales: Chen, Fang, Wang, Xingyan, Jang, Seon-Kyeong, Quach, Bryan C., Weissenkampen, J. Dylan, Khunsriraksakul, Chachrit, Yang, Lina, Sauteraud, Renan, Albert, Christine M., Allred, Nicholette D. D., Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Barr, R. Graham, Becker, Diane M., Bielak, Lawrence F., Bis, Joshua C., Blangero, John, Boorgula, Meher Preethi, Chasman, Daniel I., Chavan, Sameer, Chen, Yii-Der I., Chuang, Lee-Ming, Correa, Adolfo, Curran, Joanne E., David, Sean P., Fuentes, Lisa de las, Deka, Ranjan, Duggirala, Ravindranath, Faul, Jessica D., Garrett, Melanie E., Gharib, Sina A., Guo, Xiuqing, Hall, Michael E., Hawley, Nicola L., He, Jiang, Hobbs, Brian D., Hokanson, John E., Hsiung, Chao A., Hwang, Shih-Jen, Hyde, Thomas M., Irvin, Marguerite R., Jaffe, Andrew E., Johnson, Eric O., Kaplan, Robert, Kardia, Sharon L. R., Kaufman, Joel D., Kelly, Tanika N., Kleinman, Joel E., Kooperberg, Charles, Lee, I-Te, Levy, Daniel, Lutz, Sharon M., Manichaikul, Ani W., Martin, Lisa W., Marx, Olivia, McGarvey, Stephen T., Minster, Ryan L., Moll, Matthew, Moussa, Karine A., Naseri, Take, North, Kari E., Oelsner, Elizabeth C., Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Rafaels, Nicholas, Raffield, Laura M., Reupena, Muagututi’a Sefuiva, Rich, Stephen S., Rotter, Jerome I., Schwartz, David A., Shadyab, Aladdin H., Sheu, Wayne H-H., Sims, Mario, Smith, Jennifer A., Sun, Xiao, Taylor, Kent D., Telen, Marilyn J., Watson, Harold, Weeks, Daniel E., Weir, David R., Yanek, Lisa R., Young, Kendra A., Young, Kristin L., Zhao, Wei, Hancock, Dana B., Jiang, Bibo, Vrieze, Scott, Liu, Dajiang J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925385/
https://www.ncbi.nlm.nih.gov/pubmed/36702996
http://dx.doi.org/10.1038/s41588-022-01282-x

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