Loss of Lkb1 in CD11c(+) myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance

Adipose tissue CD11c(+) myeloid cell is an independent risk factor associated with obesity and metabolic disorders. However, the underlying molecular basis remains elusive. Here, we demonstrated that liver kinase B1 (Lkb1), a key bioenergetic sensor, is involved in CD11c(+) cell-mediated immune resp...

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Detalles Bibliográficos
Autores principales: Sun, Yunyan, Wang, Bing, Hu, Qianwen, Zhang, Haixiao, Lai, Xun, Wang, Tier, Zhao, Chunxiao, Wang, Jiali, Zhang, Xi, Niu, Qing, He, Baolin, Jiang, Erlie, Shi, Mingxia, Feng, Xiaoming, Luo, Yuechen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925521/
https://www.ncbi.nlm.nih.gov/pubmed/36781473
http://dx.doi.org/10.1007/s00018-023-04707-w

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