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Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status

Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social...

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Autores principales: Ford, Aiden, Kovacs-Balint, Zsofia A., Wang, Arick, Feczko, Eric, Earl, Eric, Miranda-Domínguez, Óscar, Li, Longchuan, Styner, Martin, Fair, Damien, Jones, Warren, Bachevalier, Jocelyne, Sánchez, Mar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925610/
https://www.ncbi.nlm.nih.gov/pubmed/36774827
http://dx.doi.org/10.1016/j.dcn.2023.101213
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author Ford, Aiden
Kovacs-Balint, Zsofia A.
Wang, Arick
Feczko, Eric
Earl, Eric
Miranda-Domínguez, Óscar
Li, Longchuan
Styner, Martin
Fair, Damien
Jones, Warren
Bachevalier, Jocelyne
Sánchez, Mar M.
author_facet Ford, Aiden
Kovacs-Balint, Zsofia A.
Wang, Arick
Feczko, Eric
Earl, Eric
Miranda-Domínguez, Óscar
Li, Longchuan
Styner, Martin
Fair, Damien
Jones, Warren
Bachevalier, Jocelyne
Sánchez, Mar M.
author_sort Ford, Aiden
collection PubMed
description Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy.
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spelling pubmed-99256102023-02-15 Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status Ford, Aiden Kovacs-Balint, Zsofia A. Wang, Arick Feczko, Eric Earl, Eric Miranda-Domínguez, Óscar Li, Longchuan Styner, Martin Fair, Damien Jones, Warren Bachevalier, Jocelyne Sánchez, Mar M. Dev Cogn Neurosci Original Research Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy. Elsevier 2023-02-08 /pmc/articles/PMC9925610/ /pubmed/36774827 http://dx.doi.org/10.1016/j.dcn.2023.101213 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Ford, Aiden
Kovacs-Balint, Zsofia A.
Wang, Arick
Feczko, Eric
Earl, Eric
Miranda-Domínguez, Óscar
Li, Longchuan
Styner, Martin
Fair, Damien
Jones, Warren
Bachevalier, Jocelyne
Sánchez, Mar M.
Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title_full Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title_fullStr Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title_full_unstemmed Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title_short Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
title_sort functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: effects of social status
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925610/
https://www.ncbi.nlm.nih.gov/pubmed/36774827
http://dx.doi.org/10.1016/j.dcn.2023.101213
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