VPA mediates bidirectional regulation of cell cycle progression through the PPP2R2A-Chk1 signaling axis in response to HU

Cell cycle checkpoint kinases play a pivotal role in protecting against replicative stress. In this study, valproic acid (VPA), a histone deacetylase inhibitor (HDACi), was found to promote breast cancer MCF-7 cells to traverse into G2/M phase for catastrophic injury by promoting PPP2R2A (the B-regu...

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Detalles Bibliográficos
Autores principales: Su, Benyu, Lim, David, Qi, Chenyang, Zhang, Zhongwei, Wang, Junxiao, Zhang, Fengmei, Dong, Chao, Feng, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925808/
https://www.ncbi.nlm.nih.gov/pubmed/36781846
http://dx.doi.org/10.1038/s41419-023-05649-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925808/
https://www.ncbi.nlm.nih.gov/pubmed/36781846
http://dx.doi.org/10.1038/s41419-023-05649-8

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