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Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography

To investigate angiographic characteristic features of diabetic choroidopathy, as well as choroidal vascular density (CVD) and fractal dimension (CFD) in diabetic eyes and controls using ultra-widefield (UWF) indocyanine green angiography (ICGA). All patients underwent UWF fluorescein angiography an...

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Autores principales: Choi, Sang Uk, Kim, Yoon Jeon, Lee, Joo Yong, Lee, Junyeop, Yoon, Young Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925819/
https://www.ncbi.nlm.nih.gov/pubmed/36781980
http://dx.doi.org/10.1038/s41598-023-29216-5
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author Choi, Sang Uk
Kim, Yoon Jeon
Lee, Joo Yong
Lee, Junyeop
Yoon, Young Hee
author_facet Choi, Sang Uk
Kim, Yoon Jeon
Lee, Joo Yong
Lee, Junyeop
Yoon, Young Hee
author_sort Choi, Sang Uk
collection PubMed
description To investigate angiographic characteristic features of diabetic choroidopathy, as well as choroidal vascular density (CVD) and fractal dimension (CFD) in diabetic eyes and controls using ultra-widefield (UWF) indocyanine green angiography (ICGA). All patients underwent UWF fluorescein angiography and ICGA. Using imageJ software, CVD and CFD was analyzed. SFCT was assessed using spectral-domain optical coherence tomography. The image parameters were compared based on the DR stage and the presence of diabetic macular edema (DME). One-hundred six eyes from 63 patients (59.11 ± 16.31 years; male [%]: 23 [36.5%]) were included in the DM group, and 40 eyes from 22 subjects were included in the control group. The DM group had a mean age of 59.11 ± 16.31 years and a mean HbA1c percentage of 7.72 ± 1.28%. The most common ICGA findings of DC were choroidal hyperpermeability (57.5%), hypofluorescent spots (48.1%). Salt and pepper pattern (19.8%), inverted inflow phenomenon (3.8%), choroidal arterial tortuosity (24.5%), and late choroidal non-perfusion (6.6%) were more common in advanced DR. The CVD, CFD, and SFCT increased as the DR severity progressed. The DME group had a significantly higher CFD and SFCT than the non-DME group (P < 0.001 and P = 0.019, respectively). The qualitative and quantitative UWF ICGA image analysis revealed that choroidal blood vessels became dilated, complex, and hyperpermeable as the DR progressed. These features of diabetic choroidopathy (DC) were more severe in eyes with DME than the non-DME eyes.
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spelling pubmed-99258192023-02-15 Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography Choi, Sang Uk Kim, Yoon Jeon Lee, Joo Yong Lee, Junyeop Yoon, Young Hee Sci Rep Article To investigate angiographic characteristic features of diabetic choroidopathy, as well as choroidal vascular density (CVD) and fractal dimension (CFD) in diabetic eyes and controls using ultra-widefield (UWF) indocyanine green angiography (ICGA). All patients underwent UWF fluorescein angiography and ICGA. Using imageJ software, CVD and CFD was analyzed. SFCT was assessed using spectral-domain optical coherence tomography. The image parameters were compared based on the DR stage and the presence of diabetic macular edema (DME). One-hundred six eyes from 63 patients (59.11 ± 16.31 years; male [%]: 23 [36.5%]) were included in the DM group, and 40 eyes from 22 subjects were included in the control group. The DM group had a mean age of 59.11 ± 16.31 years and a mean HbA1c percentage of 7.72 ± 1.28%. The most common ICGA findings of DC were choroidal hyperpermeability (57.5%), hypofluorescent spots (48.1%). Salt and pepper pattern (19.8%), inverted inflow phenomenon (3.8%), choroidal arterial tortuosity (24.5%), and late choroidal non-perfusion (6.6%) were more common in advanced DR. The CVD, CFD, and SFCT increased as the DR severity progressed. The DME group had a significantly higher CFD and SFCT than the non-DME group (P < 0.001 and P = 0.019, respectively). The qualitative and quantitative UWF ICGA image analysis revealed that choroidal blood vessels became dilated, complex, and hyperpermeable as the DR progressed. These features of diabetic choroidopathy (DC) were more severe in eyes with DME than the non-DME eyes. Nature Publishing Group UK 2023-02-13 /pmc/articles/PMC9925819/ /pubmed/36781980 http://dx.doi.org/10.1038/s41598-023-29216-5 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Choi, Sang Uk
Kim, Yoon Jeon
Lee, Joo Yong
Lee, Junyeop
Yoon, Young Hee
Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title_full Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title_fullStr Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title_full_unstemmed Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title_short Qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
title_sort qualitative and quantitative evaluation of diabetic choroidopathy using ultra-widefield indocyanine green angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925819/
https://www.ncbi.nlm.nih.gov/pubmed/36781980
http://dx.doi.org/10.1038/s41598-023-29216-5
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