FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP

FKBP51 plays a relevant role in sustaining cancer cells, particularly melanoma. This cochaperone participates in several signaling pathways. FKBP51 forms a complex with Akt and PHLPP, which is reported to dephosphorylate Akt. Given the recent discovery of a spliced FKBP51 isoform, in this paper, we...

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Detalles Bibliográficos
Autores principales: Tufano, Martina, Marrone, Laura, D’Ambrosio, Chiara, Di Giacomo, Valeria, Urzini, Simona, Xiao, Yichuan, Matuozzo, Monica, Scaloni, Andrea, Romano, Maria Fiammetta, Romano, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925821/
https://www.ncbi.nlm.nih.gov/pubmed/36781840
http://dx.doi.org/10.1038/s41419-023-05629-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925821/
https://www.ncbi.nlm.nih.gov/pubmed/36781840
http://dx.doi.org/10.1038/s41419-023-05629-y

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