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Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation

Inflammation and oxidative damage are closely related to the development of osteoarthritis. Bardoxolone methyl (CDDO-Me), a semisynthetic oleanane triterpenoid, plays a strong anti-inflammatory and antioxidant role. The purpose of our research was to explore fundamental mechanisms of CDDO-Me in orth...

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Detalles Bibliográficos
Autores principales:	Yang, Ruijia, Guo, Yanjing, Zong, Sujing, Ma, Zhou, Wang, Zhenyu, Zhao, Jiyu, Yang, Jinmei, Li, Liping, Chen, Chongwei, Wang, Shaowei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925876/ https://www.ncbi.nlm.nih.gov/pubmed/36798782 http://dx.doi.org/10.1016/j.heliyon.2023.e13080

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